ID A0A1B1DZG2_9APIC Unreviewed; 3869 AA.
AC A0A1B1DZG2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Adenylate and guanylate cyclase catalytic domain containing protein {ECO:0000313|EMBL:ANQ08164.1};
GN ORFNames=PCOAH_00027230 {ECO:0000313|EMBL:ANQ08164.1};
OS Plasmodium coatneyi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium.
OX NCBI_TaxID=208452 {ECO:0000313|EMBL:ANQ08164.1, ECO:0000313|Proteomes:UP000092716};
RN [1] {ECO:0000313|Proteomes:UP000092716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hackeri {ECO:0000313|Proteomes:UP000092716};
RA Chien J.-T., Pakala S.B., Geraldo J.A., Lapp S.A., Barnwell J.W.,
RA Kissinger J.C., Galinski M.R., Humphrey J.C.;
RT "First high quality genome sequence of Plasmodium coatneyi using continuous
RT long reads from single molecule, real-time sequencing.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP016247; ANQ08164.1; -; Genomic_DNA.
DR RefSeq; XP_019914859.1; XM_020059528.1.
DR EnsemblProtists; ANQ08164; ANQ08164; PCOAH_00027230.
DR GeneID; 30909451; -.
DR VEuPathDB; PlasmoDB:PCOAH_00027230; -.
DR OrthoDB; 199822at2759; -.
DR Proteomes; UP000092716; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR PANTHER; PTHR24092:SF219; GUANYLATE CYCLASE ALPHA; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF08282; Hydrolase_3; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 110..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1845..1865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1877..1897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1927..1949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1961..1984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1993..2017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2029..2053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2520..2537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2557..2578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2590..2608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2620..2648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2660..2680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3378..3402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3414..3437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3449..3474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3495..3521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2742..2925
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 3611..3745
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 606..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2206..2308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2324..2360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2847..2883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3301..3327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1501
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2253..2308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2860..2879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3305..3319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3869 AA; 444747 MW; E76EBD9EF8BF4121 CRC64;
MMEQKKIREK TNKGYKARYS GKLFGNHAKM RNQHVNENKQ QNDFTSAEAA WMEKKQKLYK
DTNNQPLWDF RKIQINPTDT EELISFPTNQ ISSNKYGTYS FLFKSLYEQF LRLPNIWFLI
ICLLEFIPAF QNLSNYMYYT KQSSIYLLAF FVCVSIVKNV YEDSRRSNID SQINNRLCHV
VDGSNSQLKA VKWMDLTVGS IIRLIENEQV PADILLLSCN NNEGLVYIET SLINGETNLN
KKCCVNETRN ENSIYGICNI RGRIICEKPN SNMESFNGSL KLDAHPRATS LSISNVVFKG
SYIKNTDYIF GVIIYTGTDT KIMKNILKSV YKSGNINREL NIYTILTIIF TFICVFISVL
CKWTEDDKFK NGIHFLLITV KDNLFESIVK YTLLYSNIVP ISILITVDLI SILQSVFIEN
DNRISTFENE LSEPSLIDET DERDECADLK NTKSSNFFRK YTFFLNNIGR RNFTPSIFSS
TNTEPNMDNR KNFIGTFDKL RAFKSYFNNK SSLLNSKSHV NSSYNRSSLG ESNSVQVNKA
NRNSHFLAKV RNAFLRKDKL VNFQANMVPK HGASYHGRVK SGGSSNTQGT LRGKIDVQSE
YQVSTHADNF PSNDKPTGLN TDGEPSRGRN PLYALFPFFR RKTNRTIDAV KKVDKMKSAS
KCHFPRDRFT PREDEYGWGI CLNSNMHGDL GNVDFIFTDK TGTLTSNEMS FNMCSIGGRT
YGGKRQKGKK VKTGKGIPSI CSRTGSSQNG YKDVKNGSSN RFFKKRYSED ALVKKISFAT
NICNESSDEG EQAAEGARKK RDHPNHHHEK WRGNNTSKNQ SDNAHSQDTD NAKKEDNMFP
NHKSSSFWSY QSKNINRKFS GNSLNKCPSF QNSVTLSSSI SPMSSSRFSA PSSSPRSSSC
VSSCTSSSSS GLSSSSSYAS YVSSCGVQNN AHSSFLYSSS NKDHHEMTND FDSIRSYSEL
GQEKNNQTHL QDDTKDETTD RGREKYPQEC PQESADLSCF LDPNYQAYLM QRKFSRPQSF
RKNMITGSVK AKCDFNDKKI YEDLNSNTWR GYYIDEFFKC MTLCHAVVPF IQFDYIRNKN
LTHFPSRSSK GVSQYIEKYN NHPKQQSNDM VKAKNELNLQ TSMGYEGMEE EEEEHQGGSK
FADRQTKWTT EMSDTAKNAK KKNETNLYNY NSLNTLNLKD EKKSNIKFKF LFNKKFRKKK
KSYTSLANSE IYKGAEKKHK SRWNTYFSLK KNKNLFSDEK NNKMSESAYI SKRISAVSFK
QISKEKLLSM NSYVSNRNSE DGAPGVDRKY KAKLRNLDER IFELAPLVNE RGSRNNIANS
VANNSACNIA GNVPNNSANA APSVYDDGAT SRKTEERNTI QHSDFDLDKC RDSRMTDNYT
SDSNAYLDAI KYQSSSLDEE CLIYTSNYIG YRLILRNKNT MCVEIDGNLH KWTIIGVNEF
TNKRGRMSIV VKPEFMQSGS ILYVKGSDTS ILSLLDLKYS SFLERAGKRR KKRKAHKGKR
QARASPTGIS SSKGRHPKKG DKLDASQGKG STSGINTDCE CPHHGTDAHP DADSNARSEN
CRFARRYRQL EKQLRKFSVR GLRTMVFAFK YLNEEETVKY KKMYDDACLS IYNKEERLEK
VAEMVETELT YLGITGVKDR LQKKVSKTIE ILGQSGIRIW MLTGDNVEYS LHISFLCKFL
NSHTKIFHAM LENTNCKKLK REGKALYELF QLEKEEKKCH EKMCLLINGK NLQTFLNHSD
LQTHFLNMAC SSDVVIACRI TAKQKAFIVQ LIKHRLTPTP NTLAIGDGAN DIAMLQEANI
GVSIMTPECI ISSGYADYCI QNFCCLRKLL FIYGSKHLYT MSIILYWNFF KNIVLILPVF
FYQAYASWSC VKIYPELLYT FFNIFWIFIP VIYYAFLQHN LNYDVLYNIP LFYALSRRKY
NMSTLKFFPW IVEGIFYSVV VFFFAYTAVR ENSHLSNGEV VTISTFGNIC FLGCFLISIV
RLFLEGSLWS PSILITCFGF FLFVFFPSIL FILLAYISND YIREVFRQTF MWAPLYILLI
LWFTTCIICY IFINFVKAVM FPNIYSVVNH WLFEQYQEKH SKYKYVYFLS GKKKFINLKK
IGRKFKHRFS RTAHKTYKFK PTMKPLNKEQ DYVINSRKCL DKQRNIHSSF SPSKGFNKEG
NSKFGKSTFD GGDVCLGCND DTHFDEEKTY GSARVTLCEQ AVHGMENMNH SEGGSEKWDA
QGGTTRKKKP GERKKTRWDN PNGGNGNDGQ QEKKAVKPSE QRDKSRLEKK HTKERGKGVD
LPKNGTEQRR DIAPSNRDIA MKAREEVELP PLKKKEANRM IADGAKNGEA NEETPRDDAT
NGEMANGEIP NGEMPNDRGD RANLIDPSSD EYTESSVPRI DEPLMVELKN CLNPLKNTFL
VDLLPQGKRF RINEEHIFFK NNERMEHIPE PLDVNKRNYH IIQNKPEFYD NESTSEFSYT
STDSLNDSNG KKKKKKEDAQ KEIVKVSNLI NRFTLAFKDM QLESGFQIHK KNKFYKIFTP
WYRFIFILLG IFFLYIWKLE SSLSKYWNIS SNASTDLFIL ILSLLLELVL LAATVTTFFQ
NIFIENFNKI ISAVVILIIT HHVVTYSITH IDGVFQAVLF PLYTFVILRL PFVNAVLCNI
IFLSLFIIRF KGDHFLDKKG LAHYIPLFIG VDVFVGFVGY RLEYNQRKNF LLEYSVEASR
RKQREILNTM LPPFVVDEMI YSELNEEGIP ISLKAEDIET VTIIFCDIYE FQNIVASIEP
TRLVEVLDRL FLCFDKCTEQ FNCTKIETVF ETYLAACGLV KKEGSESKEN KGQRDAHDSI
DFALSILQVS SHMKYEKTKH MLNGGDSFGS RAEGSENGAA KKNTLRTGIE TTRGDNGGTG
TERRPTRIRV KIGINSGRII AGVVGSKKPQ YALFGDTVNT ASRMKTTGKP DYIHISEATY
DLVKDDKTLI YEKKETEIKG KGTMTTYLLT SVIGLNYPFV DEPIDDGKGN FSSDLYLDSN
DPSNNINLDQ THNIFGFYSN RANQNNEYYI NDTIYNDEYS FNESDNDTNN EYVNLKEPSL
KDFPNEYTRD VNTHFYEIIK LRNLKIGTAV GHQLKQKDVL NMTFLNNGLN NDTTTNFNPY
IESNNNFEEM KDLDGGMNKL SLSDSLYYLN DNFIKKDPEN DNFQHRNKLG TQEIIDQHTK
QSIQNFTHSN RDLLDNNEGE YKDIQLCTRK CNTCGENYCT PNDCVNYDHV NHVSYHKMLS
NIRMNYLKNI RKDAKKDSER KEELDGRGSK GGLLSTSYVA SCLSKVFSIL GWGKRNQCRN
TQGKTQLDDP KRSAKRTSSM RGYTERTPPT IEKEDKFKRV ISLNSEWIFL KFSDKNLEAK
YRAHFYSNKS NINSIEQALI IFLVTFVMQT LISSTVSIVF VDHKFATQTL EVNYFAYWSV
RSLYTYLGFI LWLLFHYRTR PEVSSLLNIK WMIFFLNLLF ISAACVFSIA YLWAISETDQ
TTSYTIWMTN DTIEFFFYLV ILHHNTGMLF QTCILVDLLF ITMSLTFIST SVVKTITTDS
TVMLIPWYVA FNLISTYCKE SIDRRTFYAN ESAKKTENRA TELLNDMLPK HVLEEFQQDR
LKLAYTHDRL TFLFADICGF TSWANGVDAS EVLTLLQKLF AKFDNDSTKY GLYKLCTIGD
AYVAISEPVT EDNQDYDPVD GTERVLEMAY SMIRIIKEIR EKLCIPNLNM RIGLHYGSCV
GGVIGSGRLR YDLWGIDVLT GNLMESNGVP GKINVSETLK NFLLQQFKNR FIFKPHTTVR
VIYKDVKSFI ITDKKEIDAT NNSKNIHSRG YLLNRKIRRQ NHLDADLLFD GKKPSTFTRS
MCNSNSFENS HAPNRDLYYI NVKDEESNL
//
