ID A0A1B1EIQ7_VIBNA Unreviewed; 527 AA.
AC A0A1B1EIQ7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Tryptophan 2-monooxygenase {ECO:0000256|ARBA:ARBA00017871};
DE EC=1.13.12.3 {ECO:0000256|ARBA:ARBA00012535};
GN ORFNames=BA894_19670 {ECO:0000313|EMBL:ANQ28633.1};
OS Vibrio natriegens.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=691 {ECO:0000313|EMBL:ANQ28633.1, ECO:0000313|Proteomes:UP000092577};
RN [1] {ECO:0000313|EMBL:ANQ28633.1, ECO:0000313|Proteomes:UP000092577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 16374 {ECO:0000313|EMBL:ANQ28633.1,
RC ECO:0000313|Proteomes:UP000092577};
RA Weinstock M.T., Hesek E.D., Wilson C.M., Gibson D.G.;
RT "Developing Vibrio natriegens as a novel, fast-growing host for
RT biotechnology.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide;
CC Xref=Rhea:RHEA:16165, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16031, ChEBI:CHEBI:16526, ChEBI:CHEBI:57912;
CC EC=1.13.12.3; Evidence={ECO:0000256|ARBA:ARBA00000112};
CC -!- PATHWAY: Plant hormone metabolism; auxin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004814}.
CC -!- SIMILARITY: Belongs to the tryptophan 2-monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00005833}.
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DR EMBL; CP016352; ANQ28633.1; -; Genomic_DNA.
DR RefSeq; WP_065298185.1; NZ_CP016352.1.
DR AlphaFoldDB; A0A1B1EIQ7; -.
DR OrthoDB; 337830at2; -.
DR Proteomes; UP000092577; Chromosome 2.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 1.20.1440.240; -; 1.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR10742:SF342; AMINO_OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Auxin biosynthesis {ECO:0000256|ARBA:ARBA00023070};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023033}.
FT DOMAIN 61..513
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 527 AA; 58357 MW; A9DFDB0E79ADB0E7 CRC64;
MDNMGKSRRE FIQKVMAIGG AGAALATINA LSIPSAFASD LPPKMKANGN GKKVLILGGG
LAGMTSAYEL AQKGYDVQII EARSFAGGRC QTARKGMVIE ELGGTKQICD FDKGQYLNLG
PMRIPAHHRS TLYYTQKFKI PLETYINYNE DAWVYNDKQK SLPPQRMREV LADMHGYVNE
MMAKSLSSDS LDKTISDKDK ELLLAYLIRE GHLDQADLSY KGYGGRGYKL DPGALLQAGD
PTTPNDLESL LESELWNVAS SVSSHTQPKT VFQPVGGMDM IAKGFEEHTK QYISYNTEVQ
KIRQKDGKVI VDVMNLDTKK PRTLTGDFCI CTIPLSVLKQ IDSDFSPRFK EAMEAVAYTP
TCKLGIQTAT RFWETKDLIF GGHSVLTAGS PKTGNITYPS HDMFQEKGVL LSAYNFNSDA
AQFSALSPQE RFELSVRVGQ LVHGDDYKNN AEKAVSISWH LQKYNLGGWA SWTDEARDQH
YPILCEPEGN IYLAGEHMSY MNGWMAGAIE SAWDQIAKLD QAVLKAA
//
