ID A0A1B1M0Z6_STRLN Unreviewed; 337 AA.
AC A0A1B1M0Z6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Zinc-binding dehydrogenase {ECO:0000313|EMBL:QMV04265.1};
DE SubName: Full=Zinc-binding oxidoreductase {ECO:0000313|EMBL:ANS62249.1};
GN ORFNames=GJU35_00135 {ECO:0000313|EMBL:QMV04265.1}, GJU35_44785
GN {ECO:0000313|EMBL:QMV12058.1}, SLCG_0025
GN {ECO:0000313|EMBL:AXG51180.1}, SLINC_0025
GN {ECO:0000313|EMBL:ANS62249.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS62249.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS62249.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS62249.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG51180.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG51180.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV04265.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV04265.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
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DR EMBL; CP016438; ANS62249.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG51180.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV04265.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV12058.1; -; Genomic_DNA.
DR RefSeq; WP_067425037.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1M0Z6; -.
DR STRING; 1915.SLINC_0025; -.
DR KEGG; sls:SLINC_0025; -.
DR PATRIC; fig|1915.4.peg.33; -.
DR OrthoDB; 3727682at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05289; MDR_like_2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR11695; ALCOHOL DEHYDROGENASE RELATED; 1.
DR PANTHER; PTHR11695:SF294; RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092598}.
FT DOMAIN 10..330
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 337 AA; 35765 MW; E04FA9B89B562589 CRC64;
MKAFVVEKYG KDGVRAAEVP EPTVGDRDVL VKVSAAGINP LDKMVRNGEF KQLLKYKLPF
VLGHDVAGVV TRVGSAVRGF EVGDEVYARP RDLRVGGFAE FIAIDADDVA PKPASLSLEE
AAAVPLVALT AWQILVERAH VQPGQKVLIH AGAGGLGSTV IQLAKHLGAT VATTANTRSE
ELVRSLGADV VVDYAKEDFS KVLSGYDLVL DSVGGANLEK SLTVLKPGGL AISVVGPPDA
AFAKQLGAPS VLGLVMNTLS RKIRKRAKAL GVRYEFFFMQ ANGSQLRKLG ALYDSGKLRP
VIDSTFPFDQ TLEAMAYVEQ GRTKAGKVVV SIAPDND
//
