ID A0A1B1M2N3_STRLN Unreviewed; 254 AA.
AC A0A1B1M2N3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=MerR family transcriptional regulator {ECO:0000313|EMBL:QMV04829.1};
DE SubName: Full=Putative MerR-family transcriptional regulator {ECO:0000313|EMBL:ANS62900.1};
GN ORFNames=GJU35_03585 {ECO:0000313|EMBL:QMV04829.1}, SLCG_0669
GN {ECO:0000313|EMBL:AXG51824.1}, SLINC_0676
GN {ECO:0000313|EMBL:ANS62900.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS62900.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS62900.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS62900.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG51824.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG51824.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV04829.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV04829.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
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DR EMBL; CP016438; ANS62900.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG51824.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV04829.1; -; Genomic_DNA.
DR RefSeq; WP_067426580.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1M2N3; -.
DR STRING; 1915.SLINC_0676; -.
DR KEGG; sls:SLINC_0676; -.
DR PATRIC; fig|1915.4.peg.806; -.
DR OrthoDB; 9809391at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01106; HTH_TipAL-Mta; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR Gene3D; 1.10.490.50; Antibiotic binding domain of TipA-like multidrug resistance regulators; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR036244; TipA-like_antibiotic-bd.
DR InterPro; IPR012925; TipAS_dom.
DR PANTHER; PTHR30204:SF90; HTH-TYPE TRANSCRIPTIONAL ACTIVATOR TIPA; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF13411; MerR_1; 1.
DR Pfam; PF07739; TipAS; 1.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF89082; Antibiotic binding domain of TipA-like multidrug resistance regulators; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 2..71
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
SQ SEQUENCE 254 AA; 29103 MW; C197E2BA383BE90D CRC64;
MAWSIAQVAR MSKVTSRTLR HYDEIGLLPP AWIGSNGHRY YEEADLLRLQ QILLMRELDL
GLREIQAVLD SRLDQVAVLR EHHQRLLAER DRLETLARTV GRTIAELEEG EGKDRMTKIN
KPENLFDGFQ SPSDAEAEVR ERWPQAWEQS RQAVDAMTSE DTERRQREVT AQMIRMAEFM
VAGTPVSDPA VQAEVDANYQ NICRFWTPTA AAYKGVGQTY VDDPQMRANF DRIADGLAVY
QRDAMTVYAD TRLS
//
