ID A0A1B1M3A6_STRLN Unreviewed; 746 AA.
AC A0A1B1M3A6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Integral membrane protein {ECO:0000313|EMBL:ANS63120.1};
DE SubName: Full=MMPL family transporter {ECO:0000313|EMBL:QMV05032.1};
GN ORFNames=GJU35_04780 {ECO:0000313|EMBL:QMV05032.1}, SLCG_0889
GN {ECO:0000313|EMBL:AXG52044.1}, SLINC_0896
GN {ECO:0000313|EMBL:ANS63120.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS63120.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS63120.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS63120.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG52044.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG52044.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV05032.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV05032.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP016438; ANS63120.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG52044.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV05032.1; -; Genomic_DNA.
DR RefSeq; WP_067427240.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1M3A6; -.
DR STRING; 1915.SLINC_0896; -.
DR KEGG; sls:SLINC_0896; -.
DR PATRIC; fig|1915.4.peg.1059; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 176..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..330
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 720..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 78261 MW; 204CA3F49D37EB5A CRC64;
MFERMAELAI RRSRLVLIVA VLAVALMGVV GAGAFGKLKG GGFDDPASPS TRAAEVIGDK
FGGETNLVLL VRSPEGRIDT PASAETGRDL VADLKKDERL GNIVSYWETD NPDLRSKDGR
EAMVLAHVRG DTTEQRKNSI EILDTYSGTY KDALTVRAGG GAAVGADVSN QVFEDLILAE
AIAIPLTLIL LMIVFGSVVA ALLPLVIAII AIIGSFAQLF LFGSITDVAD TATNLTTALG
LGLGIDYALL MVSRFREQLT AGASVDDAVR RTVHTAGRTV AFSAATVAAA LAALLVFPHY
FLRSMGFTGV GVVVIAALST LFVMPALLKV LGHRVNSGRL PWAKPQRSDA GTPLWGRLAR
TVMRRPVFTA LPVLAVLLFA ASPLLNISFG TPDERVLPKD AESRQVSQVL RQNFGGSEDS
ALHIVIGQSV AEAPLASYAG QLAALQGVER VETSTGTYTA GQSTATGPAN PALGRPDAQR
ISVMSGLTPK SEAAESLVKR VRSVTPPPGS HPLVGGNDAV LVDAKESIAA KLPLAGALIV
LTTFLLLFLF TGSVVQPLRA LVLNLISLGA TLGVMTWIFD DGNLSSLLGF TAQPMEMTMT
VLMFCIAFGL SMDYEVFVTS RIKELHDQGA DNETAVVDGL GHTGRIVSAA AVLLAVSFFA
FGTAKLSFMQ MFGLGSGLAI LIDAIAVRGV LVPAAMRLLG RSAWYAPGFL RTFHGRYGLS
EGGPEPTPAP GPAAATPAHP ENSTRV
//
