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Entry: A0A1B1M612_STRLN
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ID   A0A1B1M612_STRLN        Unreviewed;       252 AA.
AC   A0A1B1M612;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=5-oxoprolinase subunit A {ECO:0000256|HAMAP-Rule:MF_00691};
DE            Short=5-OPase subunit A {ECO:0000256|HAMAP-Rule:MF_00691};
DE            EC=3.5.2.9 {ECO:0000256|HAMAP-Rule:MF_00691};
DE   AltName: Full=5-oxoprolinase (ATP-hydrolyzing) subunit A {ECO:0000256|HAMAP-Rule:MF_00691};
GN   Name=pxpA {ECO:0000256|HAMAP-Rule:MF_00691,
GN   ECO:0000313|EMBL:QMV05679.1};
GN   ORFNames=GJU35_08460 {ECO:0000313|EMBL:QMV05679.1}, SLCG_1590
GN   {ECO:0000313|EMBL:AXG52745.1}, SLINC_1598
GN   {ECO:0000313|EMBL:ANS63822.1};
OS   Streptomyces lincolnensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS63822.1, ECO:0000313|Proteomes:UP000092598};
RN   [1] {ECO:0000313|EMBL:ANS63822.1, ECO:0000313|Proteomes:UP000092598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS63822.1,
RC   ECO:0000313|Proteomes:UP000092598};
RA   Meng S.C.;
RT   "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT   actinobacteria.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AXG52745.1, ECO:0000313|Proteomes:UP000253884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LC-G {ECO:0000313|EMBL:AXG52745.1,
RC   ECO:0000313|Proteomes:UP000253884};
RX   PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA   Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA   Wu H., Bai L., Zhang L., Zhang B.;
RT   "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT   Streptomyces lincolnensis.";
RL   J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN   [3] {ECO:0000313|EMBL:QMV05679.1, ECO:0000313|Proteomes:UP000515335}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B48 {ECO:0000313|EMBL:QMV05679.1,
RC   ECO:0000313|Proteomes:UP000515335};
RX   PubMed=32322696;
RA   Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT   "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT   identification of crucial mutations contributing to lincomycin
RT   overproduction.";
RL   Synth Syst Biotechnol 5:37-48(2020).
CC   -!- FUNCTION: Catalyzes the cleavage of 5-oxoproline to form L-glutamate
CC       coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_00691}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate +
CC         phosphate; Xref=Rhea:RHEA:10348, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58402, ChEBI:CHEBI:456216; EC=3.5.2.9;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00691};
CC   -!- SUBUNIT: Forms a complex composed of PxpA, PxpB and PxpC.
CC       {ECO:0000256|HAMAP-Rule:MF_00691}.
CC   -!- SIMILARITY: Belongs to the LamB/PxpA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00691}.
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DR   EMBL; CP016438; ANS63822.1; -; Genomic_DNA.
DR   EMBL; CP022744; AXG52745.1; -; Genomic_DNA.
DR   EMBL; CP046024; QMV05679.1; -; Genomic_DNA.
DR   RefSeq; WP_067428713.1; NZ_CP046024.1.
DR   AlphaFoldDB; A0A1B1M612; -.
DR   STRING; 1915.SLINC_1598; -.
DR   KEGG; sls:SLINC_1598; -.
DR   PATRIC; fig|1915.4.peg.1809; -.
DR   OMA; SCNIACG; -.
DR   OrthoDB; 9773478at2; -.
DR   Proteomes; UP000092598; Chromosome.
DR   Proteomes; UP000253884; Chromosome.
DR   Proteomes; UP000515335; Chromosome.
DR   GO; GO:0017168; F:5-oxoprolinase (ATP-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd10787; LamB_YcsF_like; 1.
DR   Gene3D; 3.20.20.370; Glycoside hydrolase/deacetylase; 1.
DR   HAMAP; MF_00691; PxpA; 1.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR005501; LamB/YcsF/PxpA-like.
DR   PANTHER; PTHR30292:SF0; 5-OXOPROLINASE SUBUNIT A; 1.
DR   PANTHER; PTHR30292; UNCHARACTERIZED PROTEIN YBGL-RELATED; 1.
DR   Pfam; PF03746; LamB_YcsF; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00691};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00691, ECO:0000313|EMBL:QMV05679.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00691};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092598}.
SQ   SEQUENCE   252 AA;  26513 MW;  10E3218B75533013 CRC64;
     MASIDLNADL GEGFGRWRLT DDEQLLSVVT SANVACGFHA GDAATMRRVC ELAAERGVRI
     GAQVSYRDLA GFGRRAMDVP SAELTAEVAY QIGALEVFAR AAGSRVSYVK PHGALYNRVV
     HDEEQAGAVV AGVLLADPTL PVLGLPGSRL LTLAGQAGLP AVTEAFADRA YTDQGTLVPR
     DRDGAVVTEP QAVVARSVDL ALHGTVTALS GSRIEVRARS LCLHGDTPGA VDLARRVRER
     LEASGVRVEA FV
//
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