ID A0A1B1M7B5_STRLN Unreviewed; 677 AA.
AC A0A1B1M7B5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Protein kinase {ECO:0000313|EMBL:ANS64521.1, ECO:0000313|EMBL:QMV06344.1};
GN ORFNames=GJU35_12120 {ECO:0000313|EMBL:QMV06344.1}, SLCG_6116
GN {ECO:0000313|EMBL:AXG57271.1}, SLINC_2297
GN {ECO:0000313|EMBL:ANS64521.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS64521.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS64521.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS64521.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG57271.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG57271.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV06344.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV06344.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
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DR EMBL; CP016438; ANS64521.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG57271.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV06344.1; -; Genomic_DNA.
DR RefSeq; WP_067430686.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1M7B5; -.
DR STRING; 1915.SLINC_2297; -.
DR KEGG; sls:SLINC_2297; -.
DR PATRIC; fig|1915.4.peg.2554; -.
DR OrthoDB; 9788659at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd20335; BRcat_RBR; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031634; PknG_rubred.
DR InterPro; IPR031636; PknG_TPR.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF6; SERINE/THREONINE-PROTEIN KINASE NEKL-3; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF16919; PknG_rubred; 1.
DR Pfam; PF16918; PknG_TPR; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:ANS64521.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:ANS64521.1};
KW Transferase {ECO:0000313|EMBL:ANS64521.1}.
FT DOMAIN 102..364
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 131
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 677 AA; 73204 MW; 9C767A6E966A5BBC CRC64;
MPTGGHRVAR NVTAGVAQVR PNPWYGLELV PEGHVPELPE LPLHTAGGLL DEQHRHCANP
ACGKPVGRGH GGEPGRVEGV CPHCGTRFDF SRPLGRTVAG RYELEHVLGS GAYGAAYLAR
DRNLDTHVVL KHLNQSVAQT ALDERNALVG LRHDSIVRIL GYEPEGPHLV LEYVPGAPLV
ARDDDPLETL LAHGIRVLQA LDYLHARGLL HCDVKPLNII RFREDGATGP LDRVRLIDFG
SVRSRKDTGP VVAYTKPYAP PQEDREHAEP TPGFDLFGLG RTLLEVCSAH LKNRTAPGVH
SLELLLQRAT DVGLPERRFV SARQFGEQLS GVVRQLVAAS PTGRQVARPS ALFGSMPEPL
HGGLGVARPL GDWVRAVPDE DGLLTLPEPF SAPRLGEIAV ALPTPLADPD DPYIGESAGN
ALAESRLALR RKDAALAARA LERSGLDRWH WLHAWYSGLI ALARADTALA AHHFTEVRQA
VPGELIPQLA LGLCAECDGA RGHALAHYGT VFATAPALGA AGFGLARVLL PAGRREDAVA
TMERLAQEFG HEREARIAAV RLLGTVLSPP GTERPGTPTE DDLAQARETL AGLDLDDAAA
AGLRAEIQYA EFLRTRDRLA LSEAVRQLGA YAPTEREYVA LVDLANRLRP APERRWLRRR
GRTGRARFRD TPGTLSS
//