ID A0A1B1M7Y7_STRLN Unreviewed; 298 AA.
AC A0A1B1M7Y7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=NAD dependent epimerase/dehydratase {ECO:0000313|EMBL:ANS64749.1};
DE SubName: Full=TIGR01777 family protein {ECO:0000313|EMBL:QMV06556.1};
GN ORFNames=GJU35_13295 {ECO:0000313|EMBL:QMV06556.1}, SLCG_5889
GN {ECO:0000313|EMBL:AXG57044.1}, SLINC_2525
GN {ECO:0000313|EMBL:ANS64749.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS64749.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS64749.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS64749.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG57044.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG57044.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV06556.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV06556.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. SDR39U1 subfamily. {ECO:0000256|ARBA:ARBA00009353}.
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DR EMBL; CP016438; ANS64749.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG57044.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV06556.1; -; Genomic_DNA.
DR RefSeq; WP_067431295.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1M7Y7; -.
DR STRING; 1915.SLINC_2525; -.
DR KEGG; sls:SLINC_2525; -.
DR PATRIC; fig|1915.4.peg.2793; -.
DR OrthoDB; 9801773at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013549; DUF1731.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR010099; SDR39U1.
DR NCBIfam; TIGR01777; yfcH; 1.
DR PANTHER; PTHR11092:SF0; EPIMERASE FAMILY PROTEIN SDR39U1; 1.
DR PANTHER; PTHR11092; SUGAR NUCLEOTIDE EPIMERASE RELATED; 1.
DR Pfam; PF08338; DUF1731; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000092598}.
FT DOMAIN 6..216
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 251..295
FT /note="DUF1731"
FT /evidence="ECO:0000259|Pfam:PF08338"
SQ SEQUENCE 298 AA; 31405 MW; 341E60F27436A758 CRC64;
MQLSRIAVAG ASGLIGSALV RSLTADGHRV VRLVRHAPRS EDEVRWDPEA GRVDTAGLAG
CDAVVNLAGA GVGDHRWTEE YKTRIRSGRV LGTKALAEAA ASLDTPPRVF VNGSAIGFYG
ETGDRTVDED APPGQGFLPE LCVEWEGAAA PAEAAGIRTA FVRTGLVVSR GGGAWAKLFP
LFKAGLGGRM GDGRQYWSFV SLHDEVAAIR HLLDTDGLSG PFNVTAPQPL TNREITAAMG
RVLRRPTLFT VPAPVLNTVL GEMAGDVLGS QRVVPKRLLE SGFTFAFPGI EEAIRAGA
//
