ID A0A1B1M880_STRLN Unreviewed; 499 AA.
AC A0A1B1M880;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=FAD-binding domain-containing protein {ECO:0000259|Pfam:PF01494};
GN ORFNames=GJU35_13805 {ECO:0000313|EMBL:QMV06649.1}, SLCG_5791
GN {ECO:0000313|EMBL:AXG56946.1}, SLINC_2622
GN {ECO:0000313|EMBL:ANS64846.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS64846.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS64846.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS64846.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG56946.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG56946.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV06649.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV06649.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP016438; ANS64846.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG56946.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV06649.1; -; Genomic_DNA.
DR RefSeq; WP_067431553.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1M880; -.
DR STRING; 1915.SLINC_2622; -.
DR KEGG; sls:SLINC_2622; -.
DR PATRIC; fig|1915.4.peg.2896; -.
DR OrthoDB; 8670884at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR Gene3D; 3.30.70.2450; -; 1.
DR Gene3D; 3.40.30.120; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR43004:SF6; FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43004; TRK SYSTEM POTASSIUM UPTAKE PROTEIN; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF21274; Rng_hyd_C; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092598}.
FT DOMAIN 8..348
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 499 AA; 54343 MW; 75F8590ECA3401CD CRC64;
MERATAQADV VIAGGGPVGM LLAAELAHYG VDTVVLESRT TIDTEPKANT LHARTVQSLA
RRGYLEEARR RGAADASDDT RRKAPFHFAG ITELSVTSPG TEPAPLRKLP QADLEERFET
VARARGARIL RGHSVKETGQ TPHGVHVLAE GPDGVRTVRA AYLVGADGAR SVVREQNGFS
AETWPATVSA LMGQARLTAP DAPPPGWHRT PRGWIVSRPE ADGRRLVRTL NCTQAHPDRR
APVTPEEFRS EVSWIAGHEV ELSDITSLTR FSDFTRLARR FRQDRIFLAG DAAHVHFPIG
GQGLSTGLLD ALNLAWKLAH TVRGTAGKGL LDTYDYERRP IALRLIENTH AQLSLMRPGP
EADALRSLFT TILTTTDAHT LISGMISAQD TVYPPHSLQP SPWEGHFLTN RPFTVGSSPT
DLIDLLHEGR PLLLLRPDAA SHLTAVSTPW SHVIHTLRLS PDTDLPCDAL LIRPDGYIGW
GSDGGDPAEA LSMWFGDPR
//
