ID A0A1B1M928_STRLN Unreviewed; 401 AA.
AC A0A1B1M928;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN ORFNames=GJU35_15370 {ECO:0000313|EMBL:QMV06919.1}, SLCG_5499
GN {ECO:0000313|EMBL:AXG56654.1}, SLINC_2914
GN {ECO:0000313|EMBL:ANS65138.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS65138.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS65138.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS65138.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG56654.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG56654.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV06919.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV06919.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
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DR EMBL; CP016438; ANS65138.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG56654.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV06919.1; -; Genomic_DNA.
DR RefSeq; WP_067432391.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1M928; -.
DR STRING; 1915.SLINC_2914; -.
DR KEGG; sls:SLINC_2914; -.
DR PATRIC; fig|1915.4.peg.3215; -.
DR OrthoDB; 7294637at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13088; BNR_2; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..401
FT /note="exo-alpha-sialidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038215580"
FT DOMAIN 57..364
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13088"
FT REGION 247..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 401 AA; 41637 MW; 220C36F6AE7ECCCF CRC64;
MIPLSRTLLA AAVLLTPLTT TGHTAPTRGC AASVPYAAGE GGYDAYRIPA ALTTPRGTVL
AFAEGRHDGA GDTGNIDVVL RRSADGGCTW GPPTVVAAGG GDTRGNPAPV VDPATGAIVL
VTCSNSGAVT EAQIMRGEAT PEQGRRVFVQ HSWDDGRSFT PPYDITDQVK PAHWRWYATG
PGHAVALTGG PHAGRLVVPA NHSAAPPAGS ADTGQEPRYY GGHALYSDDG GGSWQLGFVD
SSYDGRTNAN ESSAAQLPDG RLYFGSRDQH GTVPGHRLDA HSGDGGASLD RPYAVQPALN
DVPVVQASVL QLPGPDAPLL FSGPSVPTAR RAMALWRSDD GGRTFAKALT LSEQPAAYSD
LVALDRDTVG VLYETGTTGP YASIEFRRLP VGEVMGRPRV V
//
