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Database: UniProt
Entry: A0A1B1M975_STRLN
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ID   A0A1B1M975_STRLN        Unreviewed;       633 AA.
AC   A0A1B1M975;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=DNA primase {ECO:0000256|HAMAP-Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811};
DE            EC=2.7.7.101 {ECO:0000256|HAMAP-Rule:MF_00974};
GN   Name=dnaG {ECO:0000256|HAMAP-Rule:MF_00974};
GN   ORFNames=GJU35_15035 {ECO:0000313|EMBL:QMV06861.1}, SLCG_5563
GN   {ECO:0000313|EMBL:AXG56718.1}, SLINC_2850
GN   {ECO:0000313|EMBL:ANS65074.1};
OS   Streptomyces lincolnensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS65074.1, ECO:0000313|Proteomes:UP000092598};
RN   [1] {ECO:0000313|EMBL:ANS65074.1, ECO:0000313|Proteomes:UP000092598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS65074.1,
RC   ECO:0000313|Proteomes:UP000092598};
RA   Meng S.C.;
RT   "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT   actinobacteria.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AXG56718.1, ECO:0000313|Proteomes:UP000253884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LC-G {ECO:0000313|EMBL:AXG56718.1,
RC   ECO:0000313|Proteomes:UP000253884};
RX   PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA   Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA   Wu H., Bai L., Zhang L., Zhang B.;
RT   "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT   Streptomyces lincolnensis.";
RL   J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN   [3] {ECO:0000313|EMBL:QMV06861.1, ECO:0000313|Proteomes:UP000515335}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B48 {ECO:0000313|EMBL:QMV06861.1,
RC   ECO:0000313|Proteomes:UP000515335};
RX   PubMed=32322696;
RA   Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT   "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT   identification of crucial mutations contributing to lincomycin
RT   overproduction.";
RL   Synth Syst Biotechnol 5:37-48(2020).
CC   -!- FUNCTION: RNA polymerase that catalyzes the synthesis of short RNA
CC       molecules used as primers for DNA polymerase during DNA replication.
CC       {ECO:0000256|HAMAP-Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.;
CC         EC=2.7.7.101; Evidence={ECO:0000256|HAMAP-Rule:MF_00974};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00974,
CC         ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|PIRSR:PIRSR002811-1};
CC       Note=Binds 1 zinc ion per monomer. {ECO:0000256|HAMAP-Rule:MF_00974,
CC       ECO:0000256|PIRNR:PIRNR002811, ECO:0000256|PIRSR:PIRSR002811-1};
CC   -!- SUBUNIT: Monomer. Interacts with DnaB. {ECO:0000256|HAMAP-
CC       Rule:MF_00974}.
CC   -!- DOMAIN: Contains an N-terminal zinc-binding domain, a central core
CC       domain that contains the primase activity, and a C-terminal DnaB-
CC       binding domain. {ECO:0000256|HAMAP-Rule:MF_00974}.
CC   -!- SIMILARITY: Belongs to the DnaG primase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00974, ECO:0000256|PIRNR:PIRNR002811}.
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DR   EMBL; CP016438; ANS65074.1; -; Genomic_DNA.
DR   EMBL; CP022744; AXG56718.1; -; Genomic_DNA.
DR   EMBL; CP046024; QMV06861.1; -; Genomic_DNA.
DR   RefSeq; WP_067432229.1; NZ_CP046024.1.
DR   AlphaFoldDB; A0A1B1M975; -.
DR   STRING; 1915.SLINC_2850; -.
DR   KEGG; sls:SLINC_2850; -.
DR   PATRIC; fig|1915.4.peg.3144; -.
DR   OMA; LMWPIRD; -.
DR   OrthoDB; 9803773at2; -.
DR   Proteomes; UP000092598; Chromosome.
DR   Proteomes; UP000253884; Chromosome.
DR   Proteomes; UP000515335; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003896; F:DNA primase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   CDD; cd03364; TOPRIM_DnaG_primases; 1.
DR   Gene3D; 3.40.1360.10; -; 1.
DR   Gene3D; 3.90.980.10; DNA primase, catalytic core, N-terminal domain; 1.
DR   Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR   HAMAP; MF_00974; DNA_primase_DnaG; 1.
DR   InterPro; IPR037068; DNA_primase_core_N_sf.
DR   InterPro; IPR019475; DNA_primase_DnaB-bd.
DR   InterPro; IPR006295; DNA_primase_DnaG.
DR   InterPro; IPR013173; DNA_primase_DnaG_DnaB-bd_dom.
DR   InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR   InterPro; IPR030846; DnaG_bac.
DR   InterPro; IPR013264; DNAG_N.
DR   InterPro; IPR034151; TOPRIM_DnaG_bac.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR002694; Znf_CHC2.
DR   NCBIfam; TIGR01391; dnaG; 1.
DR   PANTHER; PTHR30313; DNA PRIMASE; 1.
DR   PANTHER; PTHR30313:SF2; DNA PRIMASE; 1.
DR   Pfam; PF10410; DnaB_bind; 1.
DR   Pfam; PF08278; DnaG_DnaB_bind; 1.
DR   Pfam; PF08275; DNAG_N; 1.
DR   Pfam; PF13662; Toprim_4; 1.
DR   Pfam; PF01807; zf-CHC2; 1.
DR   PIRSF; PIRSF002811; DnaG; 1.
DR   SMART; SM00766; DnaG_DnaB_bind; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SMART; SM00400; ZnF_CHCC; 1.
DR   SUPFAM; SSF56731; DNA primase core; 1.
DR   SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_00974};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00974};
KW   DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW   ECO:0000256|HAMAP-Rule:MF_00974};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00974};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW   Rule:MF_00974};
KW   Primosome {ECO:0000256|ARBA:ARBA00022515, ECO:0000256|HAMAP-Rule:MF_00974};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00974};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00974};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00974};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW   Rule:MF_00974}.
FT   DOMAIN          262..346
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   ZN_FING         41..65
FT                   /note="CHC2-type"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00974,
FT                   ECO:0000256|PIRSR:PIRSR002811-1"
FT   REGION          444..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  69160 MW;  146D168F7E2BA1D1 CRC64;
     MAGRINDEDV KAVRDAVPID AVVSEYLQLR NAGGGNLKGL CPFHDEKSPS FQVSPSKGLF
     HCFGCQEGGD TITFVMKVDH LSFSEVVERL AAQAGITLRY EEGGYNPSHQ RGERIRLVEA
     HKIAADWYME QLAMSPEADT GRQFLAERGF DQGAAQHFSV GYSPQGWDHL TRYLRGKGFT
     DKELLLSGLS QEGRRGPIDR FRGRLMWPIR DIGGEVVGFG ARKLYEADNG PKYLNTPETA
     IYKKSQVLYG IDLAKKDIAK ASRAVVVEGY TDVMACHLAG VTTAIATCGT AFGGDHIKIL
     RRLLMDNGSA RVIFTFDGDA AGQKAALRAF EDDQKFAAET YIAIAPDGMD PCDLRLNKGD
     EAVADLVEPR TPLFEFALRQ IVVRYDLDTP AGRAAALDEA APIVARIKNS GAQHEVAVQL
     AGMLGILDTQ FVVKRVAQLA RWARDRGGKG PAPAHRGGPQ YDAAPRQAAS GPALTLRNPV
     YATERELLKL ALQRPELVAP AFDAYGIDEF TAAPYAAVRQ AVMEAGGVEY GVQDPQDYLV
     RVREAAPDDT VRAMVTELAV EAIMRRTVDE NYAGEQLVWV RRRAVDRRIQ EVQGTLIRLG
     SGGDPAHLAA VQNELWTLQQ YGQALREHGA AAL
//
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