ID A0A1B1MDJ6_STRLN Unreviewed; 1022 AA.
AC A0A1B1MDJ6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Tetratricopeptide repeat protein {ECO:0000313|EMBL:QMV07934.1};
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:ANS66706.1};
GN ORFNames=GJU35_21215 {ECO:0000313|EMBL:QMV07934.1}, SLCG_4422
GN {ECO:0000313|EMBL:AXG55577.1}, SLINC_4482
GN {ECO:0000313|EMBL:ANS66706.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS66706.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS66706.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS66706.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG55577.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG55577.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV07934.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV07934.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP016438; ANS66706.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG55577.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV07934.1; -; Genomic_DNA.
DR RefSeq; WP_067436704.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1MDJ6; -.
DR STRING; 1915.SLINC_4482; -.
DR KEGG; sls:SLINC_4482; -.
DR PATRIC; fig|1915.4.peg.4955; -.
DR OrthoDB; 581105at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 3.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 6.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 17..94
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|SMART:SM00862"
FT DOMAIN 101..245
FT /note="Bacterial transcriptional activator"
FT /evidence="ECO:0000259|SMART:SM01043"
FT REGION 257..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1022 AA; 111648 MW; 4615EAFD77471B58 CRC64;
MEFEIRLSGS VEIRAAGHRS DLGSTKTRVT LAALAWDAGR TVSVDTLIHR IWDEHPPAKA
REALHAHISR IRGSLRIAGD HMPAIVSRTN SYCLEIDPDQ VDLRCYTSCV ERARSLRERR
DEEAALRLLD RAEGLWHGEP LAGIAGSWAE HLRVTIGETT LVAAMTRAEI LFDAGKFADA
VPVLLPLAEA HPVDEALAEQ LAVALYGSNR TAEATRLLQR TRQRVVRDIG LDAGRGLHRV
HQGILAGNPA AALLSRAGAE ERTAPPPTRR VPDNLPRDVP WSGRRDELRR LTAALCEERG
ASDVVTVEAI HGMGGVGKTG LALHLAHRLR DRFPDGRVFL HLGGSSTDRT PLTPARALAE
LLRLLGVPAK ELPHQLDELV ALWRSTARDR RMLVILDDAT SSDQIRPLLP GASPTAVVVT
SRRRLPGLPG VRPVSLDVLP PVDAVALFRQ RLGGGRDTDS SDVAEIVRIC GYLPLAVEIA
ASRLLARASW TTSDLLRQLG GGRGHLSQLH DSDRTLTHVF AVSYDALNAE QQLVFRRIGL
HVGVEFGPRA ITALTGFSLD KAERVLEELL SHHLVSEPVP HRFIMHDLLR DYARSLIEAA
DSEDDVRQAV QGLVDHYVHA ADRADRLAYP FRSRTELDAD DPAIPSCPGI VDAQSAEQWL
ITESANLLDT LGWIAKHGSE YQLALSVHVL AGFLDMEGHL SVAEPLLRRA AAHWKAAGDS
AARVRALLDL CAVRTHGSRY DEAISAAREA LDVMRSLPDR GLEAECIHQL SVPLWQTGQY
AQARSLQKTS MNFLLRTNDL LRIARCRNLL GITHLHLAEN EEALACFTSA LADFTEIGDE
RGRYSALNNM AELYKRTGRP ADAEAAYRKA MVVADRMGNP RDRATLQMNL ASVLDVLGRT
DEALALYGLV LPVLRAVGDR RAEAIALTGI GRAYRAAGRT EEALRQHIAA LEMTRAIRAA
GDEVNVLYDL ALAERDAGHA ALAVVHLEES LTLSRSMGAS VEEARAAEAL AELRGEVTAQ
SR
//
