ID A0A1B1MJH3_STRLN Unreviewed; 344 AA.
AC A0A1B1MJH3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ketoacyl-ACP synthase III {ECO:0000313|EMBL:QMV10267.1};
DE SubName: Full=Type III beta-ketoacyl synthase-like protein {ECO:0000313|EMBL:ANS68653.1};
GN ORFNames=GJU35_34495 {ECO:0000313|EMBL:QMV10267.1}, SLCG_1986
GN {ECO:0000313|EMBL:AXG53141.1}, SLINC_6429
GN {ECO:0000313|EMBL:ANS68653.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS68653.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS68653.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS68653.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG53141.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG53141.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV10267.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV10267.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. FabH family.
CC {ECO:0000256|ARBA:ARBA00008642}.
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DR EMBL; CP016438; ANS68653.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG53141.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV10267.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B1MJH3; -.
DR STRING; 1915.SLINC_6429; -.
DR KEGG; sls:SLINC_6429; -.
DR PATRIC; fig|1915.4.peg.7101; -.
DR OrthoDB; 9815506at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00830; KAS_III; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013751; ACP_syn_III_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR34069; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 3; 1.
DR PANTHER; PTHR34069:SF2; BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III; 1.
DR Pfam; PF08545; ACP_syn_III; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000092598}.
FT DOMAIN 129..195
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08545"
FT DOMAIN 254..343
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
SQ SEQUENCE 344 AA; 36549 MW; 9400FA44FA2C5A85 CRC64;
MSTPRIPLDG AGPPVVLSGV GHYFPGEPVT NDYFEGLPGL GVDDAWIRTH TGVGSRHWAG
PDERFAEMGV KAARAALDDA GLDVSDVDVI IGTSATARPR ANPSSLGNNY MDISLPVQKQ
LGARDAFCFD VSAVACAGFL YASVVARGLL ATGQARTVLV VCAESPRAIL NFDFRNSALF
GAGAAAAVWR IGESTGAGAD RLSARGGLID VVLRADGRYY DAFDIDENDK MVMRGGILSE
VTPDMLVEAG QTVLKRNGLS PEQISWCVPH QANTNLLYPM ADRIGIPRER MLLNLPRRGN
TSSVGMPGAL SEFVRDGTVK PGQLILGVSI GRGLSWGAMV FRYR
//
