ID A0A1B1MKZ4_STRLN Unreviewed; 221 AA.
AC A0A1B1MKZ4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:ANS69279.1, ECO:0000313|EMBL:QMV10862.1};
GN ORFNames=GJU35_37745 {ECO:0000313|EMBL:QMV10862.1}, SLCG_7043
GN {ECO:0000313|EMBL:AXG58198.1}, SLINC_7055
GN {ECO:0000313|EMBL:ANS69279.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS69279.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS69279.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS69279.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG58198.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG58198.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV10862.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV10862.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
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DR EMBL; CP016438; ANS69279.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG58198.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV10862.1; -; Genomic_DNA.
DR RefSeq; WP_067442855.1; NZ_CP046024.1.
DR AlphaFoldDB; A0A1B1MKZ4; -.
DR STRING; 1915.SLINC_7055; -.
DR KEGG; sls:SLINC_7055; -.
DR PATRIC; fig|1915.4.peg.7772; -.
DR OrthoDB; 4726108at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR041474; NicS_C.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30328:SF54; HTH-TYPE TRANSCRIPTIONAL REPRESSOR SCO4008; 1.
DR PANTHER; PTHR30328; TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF17938; TetR_C_29; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00335}; Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 18..78
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 41..60
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 221 AA; 24673 MW; D1E1F16492144FC4 CRC64;
MTSVEEPARQ GGRIRDAART QAEILDVATQ EFARVGFAGA RVDEIAARTR TTKRMIYYYF
GGKEQLFTAV LERAYGVIRE AEQSLDVEHL DPVAAIRRLA ELTFDHHEQH PDFIRLVSIE
NIHGAEHIAA SEKLGKIGSP ALDVIGRILE QGQKSGLFTA DVDAVDLHAM ISSFCFFRVA
NRHTFGALFG RDLVDPGQRE HYRNMLGDMV IAYLTADRAT D
//
