ID A0A1B1MND4_STRLN Unreviewed; 1340 AA.
AC A0A1B1MND4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Helix-turn-helix domain-containing protein {ECO:0000313|EMBL:QMV11602.1};
DE SubName: Full=Transcriptional regulator, XRE family {ECO:0000313|EMBL:ANS70106.1};
GN ORFNames=GJU35_41945 {ECO:0000313|EMBL:QMV11602.1}, SLCG_7848
GN {ECO:0000313|EMBL:AXG59003.1}, SLINC_7882
GN {ECO:0000313|EMBL:ANS70106.1};
OS Streptomyces lincolnensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1915 {ECO:0000313|EMBL:ANS70106.1, ECO:0000313|Proteomes:UP000092598};
RN [1] {ECO:0000313|EMBL:ANS70106.1, ECO:0000313|Proteomes:UP000092598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2936 {ECO:0000313|EMBL:ANS70106.1,
RC ECO:0000313|Proteomes:UP000092598};
RA Meng S.C.;
RT "Enhancement of antibiotic productionsby engineered nitrateutilization in
RT actinobacteria.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXG59003.1, ECO:0000313|Proteomes:UP000253884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LC-G {ECO:0000313|EMBL:AXG59003.1,
RC ECO:0000313|Proteomes:UP000253884};
RX PubMed=29574602; DOI=10.1007/s10295-018-2029-1;
RA Xu Y., Tan G., Ke M., Li J., Tang Y., Meng S., Niu J., Wang Y., Liu R.,
RA Wu H., Bai L., Zhang L., Zhang B.;
RT "Enhanced lincomycin production by co-overexpression of metK1 and metK2 in
RT Streptomyces lincolnensis.";
RL J. Ind. Microbiol. Biotechnol. 45:345-355(2018).
RN [3] {ECO:0000313|EMBL:QMV11602.1, ECO:0000313|Proteomes:UP000515335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48 {ECO:0000313|EMBL:QMV11602.1,
RC ECO:0000313|Proteomes:UP000515335};
RX PubMed=32322696;
RA Wang R., Kong F., Wu H., Hou B., Kang Y., Cao Y., Duan S., Ye J., Zhang H.;
RT "Complete genome sequence of high-yield strain S. lincolnensis B48 and
RT identification of crucial mutations contributing to lincomycin
RT overproduction.";
RL Synth Syst Biotechnol 5:37-48(2020).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; CP016438; ANS70106.1; -; Genomic_DNA.
DR EMBL; CP022744; AXG59003.1; -; Genomic_DNA.
DR EMBL; CP046024; QMV11602.1; -; Genomic_DNA.
DR RefSeq; WP_067443605.1; NZ_CP046024.1.
DR STRING; 1915.SLINC_7882; -.
DR KEGG; sls:SLINC_7882; -.
DR PATRIC; fig|1915.4.peg.8665; -.
DR OrthoDB; 134501at2; -.
DR Proteomes; UP000092598; Chromosome.
DR Proteomes; UP000253884; Chromosome.
DR Proteomes; UP000515335; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR049052; nSTAND1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44129:SF1; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA; 1.
DR PANTHER; PTHR44129; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR Pfam; PF13560; HTH_31; 1.
DR Pfam; PF20703; nSTAND1; 2.
DR Pfam; PF00400; WD40; 12.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00530; HTH_XRE; 1.
DR SMART; SM00320; WD40; 14.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50943; HTH_CROC1; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 11.
DR PROSITE; PS50294; WD_REPEATS_REGION; 8.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000092598};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 33..91
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT REPEAT 697..738
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 750..784
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 789..820
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 834..865
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 879..920
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 932..966
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1091..1132
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1136..1167
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1180..1214
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1226..1267
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1271..1312
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1340 AA; 141431 MW; 9D7C7563CC846707 CRC64;
MGRDEQDGHH GREDNGDADP DGIASAADFG RLLTAARLRA GLTVRDVADT VRIASSTAGD
YFSGRHLPPV RSPELLAAIL RACGVDDPDV LRRWNEALVR VRMTPGRPRP GSPPPYRGLR
AFEEAHADWF FGREDLTRRL TDRLRCLAAD GEDGVPPEAR ASAGPPTEET DGDSPTAGGA
DGGPPAEGDT GARLAATGDS VAGPASRGTG RHVPLARGAV GGGLLAVVGP SGSGKSSLLR
AGLIPAVRGG AVDRAVVLMT PGRDPVAELT RRLTEAGPAP LVVVDQFEEL FTAGARETVR
RRFVELLPPA PALVVIGLRA DFYAQALRYP RLAEALQNHQ VVVGPLSAEE MRRAITGPAR
KARLEVESGL VELLARDLAP RSGGASQESA AAHDPGSLPL LSHALHATWQ RAPRGRLTVE
AYRASGGIHD AVSRTAETVF AELSDVQREL ARLVFLRLVH VTDDTLPTRR RAQRRELEGL
AGPDRAPSAE PAAVLAAFVE QRLITADSET VEISHESLLS AWPRLQEWIG ADRAGLRVHR
RLTEAARGWD ESGRDPGLLL RGTALALTGE WAADAAHREA VNTRERAFLD ASARHEDEER
RAARRRTRRL RQLLATALAL LLVASGLSVY AERQRSRADR ARTEAVSREL AAEADRIGAH
DPAVSAQLAL AAYRTAPTQE ARARLMDSSA APTATRLTGF TGLVQSVALD AGRRLLAAGS
SDGTVRLWST TDRSRPERLS RLRVSAELAV FAVALSPDGR ILVAGGGKGL LRRWDVSDPR
RPRPLPALAG ASAETVYALA FVPGGRGLAA AGADGTARLW ADGQAAGAAR PVVFRGGGDF
LQAVAFSADG ALLAASGRDG RARLWRTGGA SGARPLATLE AFDGSALSVA FSPDGRFLAA
GSQDRTTRVW DVSDPARPRR APDAGGEATS WVNAVAFGPD SGVLAIGGSD DAVRLWDRAA
GHVTATLPHP GAVTSVVWFD ARTLVTACAD GVTRLWSLPS PVLTSAEGVN ALAYSPDSRL
LAVGTLHLQL WDVARHERVG RPWKPGGDTF VQSVAFAPRQ RLLAVGYGDG LARLFSYTPD
GGLSPRGAPF RAAATGTVES LAFAPSGTVL VTGADDATVR LWDVRRADRV RALRTLTGAT
DALLSVSFSP DGRHVAAGGI DRAVRVWRTD GSRAEPLVTL RGPTGYVWSV AFSPDGGLLA
AGSADRTVRL WDTRDIAAPR RVGPELTGFT NYVYSVAFGR DGTTLAAGST DATVWLFDVS
EPRAPEARAV LTAATGHVYA VAFSPDGGTL AAGGEDHTVR LWSTDADAIA RRLCASLGDP
LSASEWRRFL PSLDDAPSCA
//