ID A0A1B1N0H2_9BACL Unreviewed; 474 AA.
AC A0A1B1N0H2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN ORFNames=AWM70_10225 {ECO:0000313|EMBL:ANS74927.1};
OS Paenibacillus yonginensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1462996 {ECO:0000313|EMBL:ANS74927.1, ECO:0000313|Proteomes:UP000092573};
RN [1] {ECO:0000313|EMBL:ANS74927.1, ECO:0000313|Proteomes:UP000092573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCY84 {ECO:0000313|EMBL:ANS74927.1,
RC ECO:0000313|Proteomes:UP000092573};
RA Kim Y.J., Yang D.C., Sukweenadhi J.;
RT "Complete Genome Sequence of Paenibacillus yonginensis DCY84, a novel Plant
RT Growth-Promoting Bacteria with Elicitation of Induced Systemic
RT Resistance.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
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DR EMBL; CP014167; ANS74927.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B1N0H2; -.
DR STRING; 1462996.AWM70_10225; -.
DR KEGG; pyg:AWM70_10225; -.
DR OrthoDB; 9802795at2; -.
DR Proteomes; UP000092573; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR NCBIfam; TIGR00237; xseA; 1.
DR PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_00378};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378};
KW Reference proteome {ECO:0000313|Proteomes:UP000092573}.
FT DOMAIN 20..115
FT /note="OB-fold nucleic acid binding"
FT /evidence="ECO:0000259|Pfam:PF13742"
FT DOMAIN 138..454
FT /note="Exonuclease VII large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02601"
FT REGION 297..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 53339 MW; F080768AF3F45A59 CRC64;
MPKGVRQPDK GGFAVEQRIY SIKELNRYIR MKMESDPLLS EVWVRGEISN FTHHSSGHMY
FTLKDADSRI KSIMFASHNQ RLPFIPKEGS RVIARGNVSV FERDGQYQFY ATHMQPDGIG
SLYLAYEQLK KKLGQEGLFE ASIKKAIPKF PRSIGVVTSP TGAAVRDIMI TLQRRYPQAH
IVLYPVLVQG KGAAPSIVKA IRELNRMGEA DVLIVGRGGG SLEELWAFNE EIVARAIHDS
AIPIISAVGH ETDFTIADFV ADLRAATPTA AAELAVPHIA DLKELLRQLQ RSLRQGLQHK
ASRERERLAR LQRSPALTQP RRQVLQHVQR LDMLKHRLSR TMDSRVKLTA GRYGRLHETL
LRFHPQAQLN QASAREDELT RRLKQSMAAL LKERSAALGG AIRQLDALSP LKVMSRGYSL
VYDEQEQKLI KSINQVQPGD QVKIKITDGV LDCQVWGIKP EGEEHGRTET GTEF
//
