ID A0A1B1NB57_9MICO Unreviewed; 551 AA.
AC A0A1B1NB57;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:ANS78634.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:ANS78634.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:ANS78634.1};
GN ORFNames=SGUI_1238 {ECO:0000313|EMBL:ANS78634.1};
OS Serinicoccus hydrothermalis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Ornithinimicrobiaceae; Serinicoccus.
OX NCBI_TaxID=1758689 {ECO:0000313|EMBL:ANS78634.1, ECO:0000313|Proteomes:UP000092482};
RN [1] {ECO:0000313|EMBL:ANS78634.1, ECO:0000313|Proteomes:UP000092482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT9 {ECO:0000313|EMBL:ANS78634.1,
RC ECO:0000313|Proteomes:UP000092482};
RA Tang K.;
RT "Shallow-sea hydrothermal system.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP014989; ANS78634.1; -; Genomic_DNA.
DR RefSeq; WP_066637679.1; NZ_CP014989.1.
DR AlphaFoldDB; A0A1B1NB57; -.
DR STRING; 1758689.SGUI_1238; -.
DR KEGG; serj:SGUI_1238; -.
DR PATRIC; fig|1758689.4.peg.1280; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000092482; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ANS78634.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000092482}.
FT DOMAIN 6..184
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 187..283
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 371..458
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 461..543
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 551 AA; 57621 MW; C6859B37C010A008 CRC64;
MRQVTTVGVI GLGTMGAGIV EVFARGGLDV IGVETTEELA ERGRGILQAS TDRAVAKGRL
DEAGQQDILG RVTITTRMED LAPADLVVEA VPEVMDLKHQ VFSTLDGIVG QDAVLASNTS
SLSITTIAAR TAHPERVVGM HFFNPAPVLK LVEVITTVRT DEAVRDAVVE LAERIGKKPV
VVGDRAGFVA NYLLFGYFVS ALRMLEQGHV SREDLDTAMR VGAGLPMGPC TLMDLVGLDV
CDHIGDVIYA HSRSPMHAPS AMLGRMVTAG LLGRKSGEGF YTYDRPGSGK VVGEDAVPGA
TGLSSVGVVG SGEIADELVS RLRDGGYAVT HVADAQDREE LAALADAGVV VEAAAVPGGE
LDGEDEPAPV EAGEELWELL GEICGPDTVL TTLNEDLAVA VGALSGRPEK AAVLRMHAPT
GNGQVVEIGR SGATDDDTVA TLRAVVTSIG AEPVVCRDRP GLVVDALLMP HLMDAVRMLD
EGYASVDDID TALQHGLGYP AGPFAMIDQI GAEEVLSVCE ELTEAGGLPR ESVQPSPLLI
EHVLLDRPFT G
//
