ID A0A1B1SCP9_9BACT Unreviewed; 430 AA.
AC A0A1B1SCP9; A0A1Z2XFU8;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Hemolysin {ECO:0000313|EMBL:ANU64588.1};
GN ORFNames=A4V02_13245 {ECO:0000313|EMBL:ANU64588.1};
OS Muribaculum intestinale.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Muribaculaceae;
OC Muribaculum.
OX NCBI_TaxID=1796646 {ECO:0000313|EMBL:ANU64588.1, ECO:0000313|Proteomes:UP000186351};
RN [1] {ECO:0000313|Proteomes:UP000186351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YL27 {ECO:0000313|Proteomes:UP000186351};
RA Uchimura Y., Wyss M., Brugiroux S., Limenitakis J.P., Stecher B.,
RA McCoy K.D., Macpherson A.J.;
RT "Complete Genome Sequences of Twelve Strains of a Stable Defined Moderately
RT Diverse Mouse Microbiota 2 (sDMDMm2).";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP015402; ANU64588.1; -; Genomic_DNA.
DR RefSeq; WP_068961865.1; NZ_PUEE01000008.1.
DR AlphaFoldDB; A0A1B1SCP9; -.
DR STRING; 1796646.A4V02_13245; -.
DR GeneID; 65537842; -.
DR KEGG; pary:A4V02_13245; -.
DR OrthoDB; 9798188at2; -.
DR Proteomes; UP000186351; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF33; UPF0053 PROTEIN YEGH; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000186351};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..193
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 278..335
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 430 AA; 48189 MW; 039DA1CA4E18B718 CRC64;
MDPNWSVWLI ITIVSLVLSA LFSGVEIAYI SSNRVKVEID VKRGGFIGKI INLYYSRQEL
FISTILVGNN IVLVIYGMGA AALLEPWIAV WCPNEAGILI IQTLISTAII LLTGEFFPKT
IFRINPNSSL RVFSLPIFVF WVVLYPVSAF TTWLSKALMW MAGIRNVNHT LGVLTVGDLN
QYIQTNIDER ASEAKVENEV KIFHNAIDFS STHLRDCMTP RNEIVAVNID STDRDELSAL
FTSSGRSKIL VYREDIDNVL GYIHVSELFT PDSDWKEAIK PVLFAPETLL ANKMMRRLLS
EKRSMAIVVD EFGGTAGLVS LEDLVEEIFG DIQDEHDNAR LTAREVEPGV YEFSGRCEIS
YLHDSFGIDL EESDEYQTLA GFILHNLGEI PVQGATIELD GWTLTILRRT ATRLELIRLT
KSATAGSDKE
//
