ID A0A1B1Z4U3_9BACI Unreviewed; 724 AA.
AC A0A1B1Z4U3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=ABE41_010370 {ECO:0000313|EMBL:ANX12414.1};
OS Fictibacillus arsenicus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Fictibacillus.
OX NCBI_TaxID=255247 {ECO:0000313|EMBL:ANX12414.1, ECO:0000313|Proteomes:UP000077412};
RN [1] {ECO:0000313|EMBL:ANX12414.1, ECO:0000313|Proteomes:UP000077412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G25-54 {ECO:0000313|EMBL:ANX12414.1,
RC ECO:0000313|Proteomes:UP000077412};
RA Zheng Z.;
RT "Complete genome sequence of Fictibacillus arsenicus G25-54, a strain with
RT toxicity to nematodes and a potential arsenic-resistance activity.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; CP016761; ANX12414.1; -; Genomic_DNA.
DR RefSeq; WP_066289749.1; NZ_CP016761.1.
DR AlphaFoldDB; A0A1B1Z4U3; -.
DR STRING; 255247.ABE41_010370; -.
DR KEGG; far:ABE41_010370; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000077412; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ANX12414.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077412};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 3..131
FT /note="Toprim"
FT /evidence="ECO:0000259|SMART:SM00493"
FT DOMAIN 132..227
FT /note="DNA topoisomerase type IA"
FT /evidence="ECO:0000259|SMART:SM00436"
FT DOMAIN 274..557
FT /note="DNA topoisomerase type IA DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00437"
SQ SEQUENCE 724 AA; 82488 MW; FF5AC6687CE02F20 CRC64;
MSKVVILAEK PSQAKAYSDA FSIKKKDKSF IELNPCSIFP NGAVITWGIG HLVELKQPKE
YKPEWGTWRL SSLPILPERY EFKVASGKYE QFNAVKRLFK EADIIINGCD VDREGSNIFY
SIYHMTGVRG KIIKRLWINS LEVEEVQKGF SNLHDNEKDL LLYSEAKTRQ ISDWLVGMNG
SRLYTLLLQQ KGLMDSLSIG RVQSPTTYLI YQRHLEIENF VPKPFYEIEG NFTAANGKYK
GKAKIKSEKQ EEVQQLLNQH NITGKDTGII KAVSKKEMRI KSPKLHALST LQATANKRWK
YSPKKVLDTV QKLYDKKILS YPRTDTQYIT ENEFAYLSAN LESYQDLIEN RFTTASKWPS
KRYVDGSKVQ EHYAIVPTKK VPTRAKIQVL STEERNIYFE VLNTTLAMFH HDYVYEETKV
TTDVNGLDFE TVGKTEISKG WKELFNHGSK DSSAKKDEAS TQALPKLEKG EKVKSVVKMK
EGMTTPPKPY TEGQLIFMMK TCGKSVENEE EMEILNEVEG LGTEATRSGI IETIKKHQYI
EVRKNIVHIT EKGKILCQSI EGNLLSSPSM TAKWETYLKK IGNGNGTPQA FLGSITKFLY
KLIEEVPGQL NAESIQQNID VVKKVNQNPI ALCPRCKKGS ISVNRSYYSC SEYANGCKQT
FPGKLLSKNI TEKQVKDLCT KGKTNVIKGF KPKAKEKRKF DAMLILKNDL TIGFEFPKKQ
FAKK
//
