ID A0A1B1Z4V8_9BACI Unreviewed; 864 AA.
AC A0A1B1Z4V8;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=ABE41_010130 {ECO:0000313|EMBL:ANX12369.1};
OS Fictibacillus arsenicus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Fictibacillus.
OX NCBI_TaxID=255247 {ECO:0000313|EMBL:ANX12369.1, ECO:0000313|Proteomes:UP000077412};
RN [1] {ECO:0000313|EMBL:ANX12369.1, ECO:0000313|Proteomes:UP000077412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G25-54 {ECO:0000313|EMBL:ANX12369.1,
RC ECO:0000313|Proteomes:UP000077412};
RA Zheng Z.;
RT "Complete genome sequence of Fictibacillus arsenicus G25-54, a strain with
RT toxicity to nematodes and a potential arsenic-resistance activity.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP016761; ANX12369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B1Z4V8; -.
DR STRING; 255247.ABE41_010130; -.
DR KEGG; far:ABE41_010130; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000077412; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000077412}.
FT DOMAIN 681..697
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 864 AA; 98162 MW; 14391A0B7B90520D CRC64;
MMSQYTPMIQ QYLSIKAAHQ DAFLFFRLGD FYEMFFDDAV QAAQILEITL TSRDGGSQDR
IPMCGVPYHS SAGYIKTLVE NGYKVAICEQ VEDPKQAVGV VKREVIQIIT PGTVIDDHLL
QDRENNYLVS IERENDLFAY VLCDLSTGEL KGYTYIGNQL SFIQLLLSQG VKEIVGDEEL
HTDWNEKMSL NGQASISVQQ ETTVEEKFQH LTIDITPLPL LKAAGRLFHY LNYTQKRSFQ
HLKPVEYQQN DLRMKLDAFS KRNLELTESI RAKGKKGSLL WLLDSTMTAM GARKLKQWVE
EPLFVKKTIE KRLQLVEELI NEFFIREEMK EQLKSVYDME RLIAKISYGN ASPRDLVQLK
RSLLSVPVLK EKISQIPGEY ASEIYEKMKD HKELAQFLDS AVHDEAPVQI KEGGIIKKGY
NAKLDEYKDA SMNGKAWIAA LEQKEKTETG IKSLKIGFNK IFGYYIEVTK SNLSMVPAER
YERKQTLANA ERYVTPELKE KERIILEAEE KISGLEHTLF LEVREYVKQY IPGLQQLASA
ISELDVIQSF AAISEQYRYV RPTVSEDGKV NIVGGRHPVV EKVMDAQEYV PNDIFLNNER
NMLLITGPNM AGKSTYMRQL ALTAIMMQIG CFVPAEQAEL PMFDQIFTRI GAADDLVGGQ
STFMVEMLET NFALTSATEN SLILLDEIGR GTSTYDGMAL AQSIIEFIHE RIQAKTLFST
HYHELTVLEN SLPSLKNVFV SAVEENGSLV FLHKVIDGQA DKSFGIQVAE LADLPQDVIQ
RAKTILQTYE KQEKNEALPI QEVSAAKEEV QESQLSLFAE KSTVSRKRDL KENDVLKDLK
ALNVLEMTPL EAMNALYKLH TKLK
//
