ID A0A1B2ANM6_9CAUD Unreviewed; 272 AA.
AC A0A1B2ANM6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
OS Pseudoalteromonas phage PH1.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX NCBI_TaxID=1874540 {ECO:0000313|EMBL:ANY29521.1, ECO:0000313|Proteomes:UP000203336};
RN [1] {ECO:0000313|EMBL:ANY29521.1, ECO:0000313|Proteomes:UP000203336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Z.;
RT "Isolation and Characterization of a novel Pseudoalteromonas phage PH1.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KX365747; ANY29521.1; -; Genomic_DNA.
DR RefSeq; YP_009321555.1; NC_031908.1.
DR GeneID; 30307173; -.
DR KEGG; vg:30307173; -.
DR OrthoDB; 13491at10239; -.
DR Proteomes; UP000203336; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ANY29521.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000203336};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ANY29521.1}.
FT DOMAIN 8..259
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 272 AA; 30888 MW; 712CB7D453493F07 CRC64;
MFLDFEIQYA KLVERIINNG VHKEGRNGGT RSIFGTSLEF DLSNGYLPVL QGRKSYYKGV
LGEFAALVRR PHSVADFEAW GCNYWSKWAD ESGNLVLDYG NAWFDYNGVD QIAVLKKTLR
ENPNDRRMIV NAWRPDRLDA LSLPCCHYSY QFNVENGKLN MVWTQRSADS MIGIPADMIL
AAIWVITLAN EVGLKPGRVK MDFGDTHIYA EHLDNAIEYV DRVLSGDYFA GWTYPAYALI
SPKGMDFCRF APSDLVVTDC NTLGPLHFEL KE
//
