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Database: UniProt
Entry: A0A1B3LJ72_9PROT
LinkDB: A0A1B3LJ72_9PROT
Original site: A0A1B3LJ72_9PROT 
ID   A0A1B3LJ72_9PROT        Unreviewed;       339 AA.
AC   A0A1B3LJ72;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN   ECO:0000313|EMBL:AOF80903.1};
GN   ORFNames=BSY238_3172 {ECO:0000313|EMBL:AOF80903.1};
OS   Methyloversatilis sp. RAC08.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Sterolibacteriaceae; Methyloversatilis.
OX   NCBI_TaxID=1842540 {ECO:0000313|EMBL:AOF80903.1, ECO:0000313|Proteomes:UP000094168};
RN   [1] {ECO:0000313|Proteomes:UP000094168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RAC08 {ECO:0000313|Proteomes:UP000094168};
RA   Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP016448; AOF80903.1; -; Genomic_DNA.
DR   RefSeq; WP_069039970.1; NZ_CP016448.1.
DR   AlphaFoldDB; A0A1B3LJ72; -.
DR   STRING; 1842540.BSY238_3172; -.
DR   KEGG; metr:BSY238_3172; -.
DR   PATRIC; fig|1842540.3.peg.3212; -.
DR   OrthoDB; 9783139at2; -.
DR   Proteomes; UP000094168; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000094168};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          4..72
FT                   /note="Winged helix-turn-helix transcription repressor HrcA
FT                   DNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03444"
FT   DOMAIN          104..322
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   339 AA;  37140 MW;  3F7B2C820EEAD28B CRC64;
     MLEDRSRLLL KTLVERYIAD GQPVGSRTLS KYSGLDLSPA TIRNVMSDLE ELGFITSPHT
     SAGRVPTPRG YRFFVDSLLS VQPLEPGQIS ELKGELRPAD PRVLVGQASQ LLSQLTHFAG
     IVVAPRRQMV RIRQIEFLSL SDKRILLIIV TDQGEVQNRI LLTERNFSPA ELVSAANFLN
     QNYVGFDFEE IRGRLQAELK KLHGDLTSLM AAALQAGNEA FSGDKGQYVI SGERNLLAVD
     DLASNMSRLR ELFSLFDQRT QLASLLDLSQ QAEGVQLFIG GESGLAPLDE CSVVTAPYEI
     QGQVVGSVGV IGPTRMAYER VIPIVDVTAK LLSSALSQT
//
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