ID A0A1B3SKQ5_9MOLU Unreviewed; 425 AA.
AC A0A1B3SKQ5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN ECO:0000313|EMBL:AOG60519.1};
GN ORFNames=SHELI_v1c05680 {ECO:0000313|EMBL:AOG60519.1};
OS Spiroplasma helicoides.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=216938 {ECO:0000313|EMBL:AOG60519.1, ECO:0000313|Proteomes:UP000094378};
RN [1] {ECO:0000313|EMBL:AOG60519.1, ECO:0000313|Proteomes:UP000094378}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TABS-2 {ECO:0000313|EMBL:AOG60519.1,
RC ECO:0000313|Proteomes:UP000094378};
RA Shen W.-Y., Lo W.-S., Lai Y.-C., Kuo C.-H.;
RT "Complete genome sequence of Spiroplasma helicoides TABS-2 (DSM 22551).";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
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DR EMBL; CP017015; AOG60519.1; -; Genomic_DNA.
DR RefSeq; WP_069116525.1; NZ_CP017015.1.
DR AlphaFoldDB; A0A1B3SKQ5; -.
DR STRING; 216938.SHELI_v1c05680; -.
DR KEGG; shj:SHELI_v1c05680; -.
DR PATRIC; fig|216938.3.peg.580; -.
DR OrthoDB; 9802795at2; -.
DR Proteomes; UP000094378; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR Gene3D; 2.40.50.1010; -; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR NCBIfam; TIGR00237; xseA; 1.
DR PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_00378};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378};
KW Reference proteome {ECO:0000313|Proteomes:UP000094378}.
FT DOMAIN 7..101
FT /note="OB-fold nucleic acid binding"
FT /evidence="ECO:0000259|Pfam:PF13742"
FT DOMAIN 125..414
FT /note="Exonuclease VII large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02601"
SQ SEQUENCE 425 AA; 48234 MW; F6FD4954E1B65AD1 CRC64;
MNKNILKISE LSDKIKNHLE STLNFKNISI KGEIANLTFN RSGHIYFSLK DNDSKVDCAI
WKTNAYKFVN LNLSEGTEII ALGSISFYKP SGKITFTIVD IKIDGIGELA LLYEKRYKEL
HEKGWFDKEN KQPIPNKPNN IGIVTAATGA AVEDLISTMK RRYPLVNIYL FPALVQGESA
AFDIANKIKK ANNFKIKLDL LIVGRGGGSY EDLWCFNEMP VLEAIHNSII PIISAVGHEP
DNTLADYVAD IRASTPTAAA ELATPEKDNL IKALNSVQND FVKVLLNKIN ILKNNLFNQT
SLLKNNIIQK KDKVFNNYNN EVNNFVKNMK YKINYIRNFL INNKKDFQTI LKNKIQNNKL
VLTNEYEKLK LLNPIKPLEK GFTILKQNDK IIFNIKQIDK NINLNAQLID GSIDLSVIKI
KEEDE
//
