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Entry: A0A1B4WU11_9PSED
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ID   A0A1B4WU11_9PSED        Unreviewed;       714 AA.
AC   A0A1B4WU11;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   08-MAY-2019, entry version 16.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:BAV26060.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:BAV26060.1};
DE            EC=4.2.1.17 {ECO:0000313|EMBL:BAV26060.1};
GN   ORFNames=LAB08_0790 {ECO:0000313|EMBL:BAV26060.1};
OS   Pseudomonas sp. LAB-08.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=143813 {ECO:0000313|EMBL:BAV26060.1, ECO:0000313|Proteomes:UP000218595};
RN   [1] {ECO:0000313|EMBL:BAV26060.1, ECO:0000313|Proteomes:UP000218595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Suzuki K., Fatma A., Inuzuka Y., Tashiro Y., Futamata H.;
RT   "Draft genome sequence of Pseudomonassp. LAB-08 isolated from TCE
RT   contaminated aquifer soil.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01133165};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA +
CC         H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01123900};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; AP017423; BAV26060.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000218595; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000218595};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   Lyase {ECO:0000256|SAAS:SAAS00999128, ECO:0000313|EMBL:BAV26060.1};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00999134};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296,
KW   ECO:0000313|EMBL:BAV26060.1}.
FT   DOMAIN      318    496       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      499    599       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   714 AA;  76202 MW;  8F51D68EE4551D06 CRC64;
     MTQAIRYEKG QDQIVVLTID MPGQSANTMN AVYRDAMADC VARLVADRDA IAGVIITSAK
     KTFFAGGDLN ELIKVGKPQA KAFYDMVLNL KGQLRTLETL GKPVVAAING AALGGGWEIC
     LACHHRVALD NPSVQLGLPE VTLGLLPGGG GVVRMVRMLG LEKALPYLLE GKKVRPQQAL
     QAGLIDELAA DQDELLAKAR AWIIANPTAV QRWDVKGYQI PGGTPSSPKV AQMLAIAPSI
     LRSKTQGCMP APEKILCAAV EGAQVDFDTA HLIETRYFTE LTTGQISKNL IGTFWFQLNE
     INAGGSRPQG IAPYVTRKVG VLGAGMMGAG IAFVSASAGI EVVLKDISLA AAEKGKAHSA
     ALLDKKVARG QMNSEQREAV LARIHTTESD ADLAGCDLII EAVFEDRELK AKVSLAAQKV
     VGADAVIASN TSTLPISGLA TAVPDPSKFI GLHFFSPVDK MPLVEIIKGN HTSDETLARG
     FDFVLQIKKT PIVVNDSRGF FTSRVFGTFT NEGIAMLGEG VSAPMIETEA RKAGMPIGPL
     AISDEVSLSL MSHIRQQTAK DLQAEGKPLV EHPAFAVIDL LLNEYKRPGK AAGGGFYEYP
     AGGQKHLWPQ LKTRFEKADG QISPKDVRDR LLFVQAIETV RCVEEGVLTS TADANVGSIF
     GIGFAAWTGG ALQFINQYGV KDFVARAQYL AGQYGERFAP PALLLEKAAK GETF
//
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