ID A0A1B6AHD4_9ACTN Unreviewed; 449 AA.
AC A0A1B6AHD4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=SSP35_04_01590 {ECO:0000313|EMBL:GAU67078.1};
OS Streptomyces sp. NBRC 110611.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1621259 {ECO:0000313|EMBL:GAU67078.1, ECO:0000313|Proteomes:UP000094479};
RN [1] {ECO:0000313|EMBL:GAU67078.1, ECO:0000313|Proteomes:UP000094479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110611 {ECO:0000313|EMBL:GAU67078.1,
RC ECO:0000313|Proteomes:UP000094479};
RA Igarashi Y., Komaki H., Ichikawa N., Hosoyama A., Fujita N., Panbangred W.;
RT "Whole genome shotgun sequence of Streptomyces sp. NBRC 110611.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU67078.1}.
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DR EMBL; BBUY01000004; GAU67078.1; -; Genomic_DNA.
DR RefSeq; WP_066929866.1; NZ_BBUY01000004.1.
DR AlphaFoldDB; A0A1B6AHD4; -.
DR STRING; 1621259.GCA_001590865_02388; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000094479; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000094479}.
SQ SEQUENCE 449 AA; 50214 MW; F870AB38FDCF3224 CRC64;
MTHTVPEPAD HAQQTEHDVV AIGCGPFNLG LAALASTVDG LDLVVLEEQP ELTWHRGMMF
GDASMQVNFL ADLVTLVAPS HPLSFLAYLH DMDRLYTFTV RENFFPSRRE YEDYLRWAAA
KLPSVRFSHR VDEVHWDAAA ERFSVSTVRG DGTRRRLLAR HLVLGIGTTP HVPEALAALP
PQHLLHTSDY LYRTPDVADA GKITVVGSGQ SGAEVAVDLL NRNLDGGPAV SWLTRTTSFA
PLDYTRLVLE MTTPAYMQYF HSLPEEARDR LVSEQWQFYK GISTDTLDEI HELLYRRQLE
HGLAEVELRF GITVESAATT PSGQVALTCR HRDTDQTFEH TTDLVVAATG YRNRPPAFLH
PLDDLIRRDR HGRPLVRLDH SLEFTEELGL TGRIFVANAE IHAHGVSAPN LDIGAVRNAT
ILNAITGRET YRLPKRSAFT TFEAPRQTS
//
