ID A0A1B6APL1_9ACTN Unreviewed; 348 AA.
AC A0A1B6APL1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486};
DE EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991};
DE AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00030686};
GN Name=cobT1 {ECO:0000313|EMBL:GAU69511.1};
GN ORFNames=SSP35_12_01590 {ECO:0000313|EMBL:GAU69511.1};
OS Streptomyces sp. NBRC 110611.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1621259 {ECO:0000313|EMBL:GAU69511.1, ECO:0000313|Proteomes:UP000094479};
RN [1] {ECO:0000313|EMBL:GAU69511.1, ECO:0000313|Proteomes:UP000094479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110611 {ECO:0000313|EMBL:GAU69511.1,
RC ECO:0000313|Proteomes:UP000094479};
RA Igarashi Y., Komaki H., Ichikawa N., Hosoyama A., Fujita N., Panbangred W.;
RT "Whole genome shotgun sequence of Streptomyces sp. NBRC 110611.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from
CC nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
CC {ECO:0000256|ARBA:ARBA00002197}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001058};
CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005049}.
CC -!- SIMILARITY: Belongs to the CobT family.
CC {ECO:0000256|ARBA:ARBA00007110}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU69511.1}.
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DR EMBL; BBUY01000012; GAU69511.1; -; Genomic_DNA.
DR RefSeq; WP_066935458.1; NZ_BBUY01000012.1.
DR AlphaFoldDB; A0A1B6APL1; -.
DR STRING; 1621259.GCA_001590865_04831; -.
DR OrthoDB; 9781491at2; -.
DR UniPathway; UPA00061; UER00516.
DR Proteomes; UP000094479; Unassembled WGS sequence.
DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02439; DMB-PRT_CobT; 1.
DR Gene3D; 1.10.1610.10; -; 1.
DR Gene3D; 3.40.50.10210; -; 1.
DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_bact.
DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR NCBIfam; TIGR03160; cobT_DBIPRT; 1.
DR PANTHER; PTHR43463; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43463:SF1; NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF02277; DBI_PRT; 1.
DR SUPFAM; SSF52733; Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT); 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:GAU69511.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000094479};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:GAU69511.1}.
SQ SEQUENCE 348 AA; 35897 MW; 3B3C62836054893A CRC64;
MSSLNLDDFA QLIERPDGGV RRDAEERRAR LAVPPGALGR LDELGEWLAA AQQRVPVRPV
ERPRVLLFAG DHGVAELGVS ARPAGGTKDL VRAVLDGASP AAVLARRAGA GVRVVDMAVD
CDPEELPAEV TRHRVRRGSG RIDVEDALTA EEAEAAFRAG MAIADEEADT GTDLVVLGDL
SVGGTTAAST LIAALCGTDA SVVTGRGGAG IDDLAWMRKC AAIRDALRRA RPVLGDQLEL
LAAAGGADLA AITGFLLQSA VRRTPVILDG VVSAACALVA QRVAFRAPDW WLAGQASGEP
AQAKALDRIA LNPLLDHGVT AGEGTGALLA LPLVQAAAAL AAELPERD
//
