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Database: UniProt
Entry: A0A1B6ASP4_9ACTN
LinkDB: A0A1B6ASP4_9ACTN
Original site: A0A1B6ASP4_9ACTN 
ID   A0A1B6ASP4_9ACTN        Unreviewed;       245 AA.
AC   A0A1B6ASP4;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   11-DEC-2019, entry version 14.
DE   RecName: Full=Urease {ECO:0000256|SAAS:SAAS00312638};
DE            EC=3.5.1.5 {ECO:0000256|SAAS:SAAS00312638};
GN   ORFNames=SSP35_19_01120 {ECO:0000313|EMBL:GAU70475.1};
OS   Streptomyces sp. NBRC 110611.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1621259 {ECO:0000313|EMBL:GAU70475.1, ECO:0000313|Proteomes:UP000094479};
RN   [1] {ECO:0000313|EMBL:GAU70475.1, ECO:0000313|Proteomes:UP000094479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 110611 {ECO:0000313|EMBL:GAU70475.1,
RC   ECO:0000313|Proteomes:UP000094479};
RA   Igarashi Y., Komaki H., Ichikawa N., Hosoyama A., Fujita N., Panbangred W.;
RT   "Whole genome shotgun sequence of Streptomyces sp. NBRC 110611.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC         Evidence={ECO:0000256|SAAS:SAAS01117045};
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|SAAS:SAAS00607110};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC       urea (urease route): step 1/1. {ECO:0000256|SAAS:SAAS00312627}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00534747}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Urease alpha subunit family. {ECO:0000256|SAAS:SAAS00846840}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAU70475.1}.
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DR   EMBL; BBUY01000019; GAU70475.1; -; Genomic_DNA.
DR   EnsemblBacteria; GAU70475; GAU70475; SSP35_19_01120.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000094479; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00312633};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00321417};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00321440};
KW   Nickel {ECO:0000256|SAAS:SAAS00312631};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094479}.
FT   DOMAIN          3..126
FT                   /note="Urease_alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00449"
FT   REGION          158..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..181
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..245
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   245 AA;  26369 MW;  DC9FBF21D041D6FD CRC64;
     MAELTRQAYA GLFGPTAGDR IRLADTDLVV EITEDRSGGP GRAGDEAVFG GGKVIRESMG
     QSRVTRAEGA PDTVITGAVV LDHWGIVKAD VGIRDGRITA LGKAGNPDTM DGVHPGLVIG
     PETEIIAGNG KILTAGAIDT HVHFICPQQA DEALASGLRR HHDDRRRHRT GRGQQGDHHH
     PRRLARRPDA GVDGLPAGQR RTPRQGQHHL PRLDARPAAG RRPRLQDPRG LGRHPRGARR
     LPDRL
//
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