ID A0A1B6AWI0_9ACTN Unreviewed; 716 AA.
AC A0A1B6AWI0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Beta-ketoacyl-[acyl-carrier-protein] synthase I {ECO:0000313|EMBL:GAU71643.1};
DE Flags: Fragment;
GN ORFNames=SSP35_66_00010 {ECO:0000313|EMBL:GAU71643.1};
OS Streptomyces sp. NBRC 110611.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1621259 {ECO:0000313|EMBL:GAU71643.1, ECO:0000313|Proteomes:UP000094479};
RN [1] {ECO:0000313|Proteomes:UP000094479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110611 {ECO:0000313|Proteomes:UP000094479};
RA Igarashi Y., Komaki H., Ichikawa N., Hosoyama A., Fujita N., Panbangred W.;
RT "Whole genome shotgun sequence of Streptomyces sp. NBRC 110611.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAU71643.1}.
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DR EMBL; BBUY01000066; GAU71643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B6AWI0; -.
DR Proteomes; UP000094479; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000094479};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 68..143
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 166..588
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 599..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 716
FT /evidence="ECO:0000313|EMBL:GAU71643.1"
SQ SEQUENCE 716 AA; 74326 MW; 2EA92C97E32A70B4 CRC64;
MALFDAALGS TEPMALPVRL DLTALRQQGD VPPLLRSLIR TRTRRSGAAA ASGIARRLAG
LSPVERRAAL LDVVRGRIAA VLGHTSPETV ASDRAFQDLG FDSLTAIELR NLLGKATGLR
LPATTVFDYP TADALAGHLL DELFGAEQEA GTTTHLPVSA LPSPADDPVV IVGMSCRFPG
GVASPEDLWR LVAEGVDAVS DFPTDRGWEI EDTDDPERAG AIATRSGGFL YDAADFDPEF
FGMSPREALT TDAQQRLLLE TTWEALERAG MDPATLRGSR TGVFAGVMYH DYSTLLSGRE
FEGYQGSGSA GSVASGRVSY TFGFEGPAVT VDTACSSSLV ALHLAAQSLR QGECSLALAG
GVTVMSTPLT FVEFSRQGGL AADGRCKAFS DAADGVGWAE GAGILVLERL SDARRHGHRV
LAVVRGSAVN QDGASNGLTA PNGPSQQRVI RQALTSAGLS AADVDAVEAH GTGTTLGDPI
EAQALLATYG QGRSGGRPLL LGSVKSNIGH AQAASGVAGV IKMVLAMRHG VLPRTLHVDQ
PSTHVDWSAG AVELLTSAVE WPQGEGPRRA GVSSFGISGT NAHVILEQPE PDAAVLDAGP
AAESDAELDE ASDAAARAQA PVPAPVPLSG RNEPALRAQA ARLLSHLDGA PGPRVKDVAY
SLATRRSAFP HRAVILAANR EDLLRSLSAL AEGRSEAALV AQGRTPSGSK LAFLFS
//
