ID   A0A1B6BCL0_9FIRM        Unreviewed;       668 AA.
AC   A0A1B6BCL0;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=ComE-like protein {ECO:0000313|EMBL:GAU77454.1};
GN   ORFNames=F3D3_2083 {ECO:0000313|EMBL:GAU77454.1};
OS   Fusibacter sp. 3D3.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales;
OC   Eubacteriales Family XII. Incertae Sedis; Fusibacter.
OX   NCBI_TaxID=1048380 {ECO:0000313|EMBL:GAU77454.1, ECO:0000313|Proteomes:UP000095197};
RN   [1] {ECO:0000313|EMBL:GAU77454.1, ECO:0000313|Proteomes:UP000095197}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D3 {ECO:0000313|EMBL:GAU77454.1,
RC   ECO:0000313|Proteomes:UP000095197};
RA   Serrano A.E., Escudero L.V., Encalada O., Tebes C.J., Fernandez S.,
RA   Demergasso C.S.;
RT   "Draft genome sequence of Fusibacter ascotence 3D3 isolated from the high
RT   arsenic level Ascotan salt flat in northern Chile.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAU77454.1}.
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DR   EMBL; BDHH01000007; GAU77454.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B6BCL0; -.
DR   STRING; 1048380.F3D3_2083; -.
DR   Proteomes; UP000095197; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095197};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        168..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        240..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        292..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        326..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          440..618
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   668 AA;  76531 MW;  66EDBEDF820661B8 CRC64;
     MKRVEAYRNA TPSNIKQTAS LKTLDGNVVS LNTEKGTLIF KPKALEHKIM ITYNVENIDA
     RTLEHEIIEE KTAFKMEIDL NERQFRETHN AYEFDYQKYL YANNVIGQYH LKSYEVSDGL
     KKSILAHFNS RRMKLMRLVE NLKVAEYFNA LILGHNDSLS EKDLFRRLGI SHVFAISGMH
     FGLIYASLYK LIKGPRGCKS ILTMGLLICY WGLIGFSYSA GRAVFLVIYV EVSRMLSRKI
     DALSAVALTN LILLFIFPNA VLAVSYQLSF IAYLLIAYVY QRLNRHKKMH KMIGSFYFVF
     FIQIAFLPIQ LYYFNEVNLL AFLPNLIIVP LISALFPFFF LIPLLGTSIV WLLEKCLHGI
     EFVAKLMPIW CVEGQILTPS QFKIIFIFAF VYFVYKSIRI SQSLILKKSQ MTFMALMTSW
     MIISGFNFSK SEIHFFDVGH GDSALIMNDH HPILIDTGDP YTDLTQMLIK RDIYKIDALI
     LSHAHSDHVG GLKQLAETYP IYQIYCNQET YEVIKADISA STEVIVVKSP IEITLANARL
     TLIPSESDDT NDNAIAVWYD SKEIKGIFLG DISGPVYEKF PSVLTELDFV KIAHHGSKTG
     LSKSFLKEHP IKYAIISHNE KYLMPNKSIL DQLEEEGIEI YKTYNCGEII LNKRGIFSYL
     THKSTVNP
//