ID A0A1B6P5T7_SORBI Unreviewed; 792 AA.
AC A0A1B6P5T7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 24.
DE RecName: Full=Retinoblastoma-related protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SORBI_3009G010600 {ECO:0000313|EMBL:KXG21077.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:KXG21077.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:KXG21077.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication.
CC {ECO:0000256|ARBA:ARBA00025018}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; CM000768; KXG21077.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B6P5T7; -.
DR EnsemblPlants; KXG21077; KXG21077; SORBI_3009G010600.
DR Gramene; KXG21077; KXG21077; SORBI_3009G010600.
DR Proteomes; UP000000768; Chromosome 9.
DR ExpressionAtlas; A0A1B6P5T7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF22; RETINOBLASTOMA-RELATED PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 10..103
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 281..482
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 87435 MW; DACF81C4BCF5D629 CRC64;
MSSPDPSPAT STPSPATSTQ QKQSESLVNL LAEASRFYRR AYNELFSGVT TEQEPESSTN
TPEYMLFGWY LFLMLHSRSP ELFKDLVSCI HGLVAVLAIL LIHVPVKFRS FTVEGSSHLI
KQTEKGMDLI ASLCHNYHAS EERLKEMMDK SHKAIEDVFG MKALSASECK TENLDMIGTD
GLMYFKGLID MECFQSNLEK MEKLCNSNSS EGKLDFKSIL INNDYIPCAE NLSGDSTNLG
HSKHVFEILA SPTKTIKNML TVPSSPLSPA TSGSVKIVQM TPVTSAMTTA KWLREVISSL
PEKPSSKLQQ LLSSCDRDLT NAVTERVSIV LEAIFPTKSS ADGGGSLGLN CANVFDIPWA
EARKMEASKL YYRVLEAICR AELQNSNVNN LTPLLLNERF HRCLIACSAE LVLATHKPVF
MMFPAVLEST GLTAFDLSKI IENFVRHEET LPRQLKRHLN SLEEQLLESM VWEKGSSLYN
SLIVARPSIA SEIKHLGLLA EPMPSLDDLV ARQNIHVEGL PATPSKKRDA GPDDNADPRS
PKRSCNESRN TVVEHNLLTP PPKHHMVSTS LKAKCHPLES TFASPTVSNP VGGNEKCADV
AIQIFFSKIL DQQTTLFFNR HIDQLILCCL YGVAKACKVE LSFKELLNYY RKEAQCKPEV
FQNIYIGSRN SNDVLVSRHV SIISFYNAVF VPAAKPFLVS LISSGTCPED KKNASGPIPG
SPKPSPLPNN LPDMSPKKVS ASHNVYVSPL RQTKMDALLS PSSRSFYACI GEGTHAYQSP
SKDLAAINSR LN
//
