ID A0A1B6Q610_SORBI Unreviewed; 515 AA.
AC A0A1B6Q610;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Protein cereblon {ECO:0000256|ARBA:ARBA00014394};
GN ORFNames=SORBI_3003G292500 {ECO:0000313|EMBL:KXG33353.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:KXG33353.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:KXG33353.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the 4-toluene sulfonate uptake permease (TSUP)
CC (TC 2.A.102) family. {ECO:0000256|ARBA:ARBA00009142}.
CC -!- SIMILARITY: Belongs to the CRBN family.
CC {ECO:0000256|ARBA:ARBA00005293}.
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DR EMBL; CM000762; KXG33353.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B6Q610; -.
DR EnsemblPlants; KXG33353; KXG33353; SORBI_3003G292500.
DR Gramene; KXG33353; KXG33353; SORBI_3003G292500.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000768; Chromosome 3.
DR ExpressionAtlas; A0A1B6Q610; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd15777; CRBN_C_like; 1.
DR Gene3D; 1.20.58.1480; -; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 2.170.150.20; Peptide methionine sulfoxide reductase; 1.
DR InterPro; IPR034750; CULT.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR PANTHER; PTHR14255:SF23; ATP-DEPENDENT PROTEASE LA (LON) DOMAIN-CONTAINING PROTEIN-LIKE; 1.
DR PANTHER; PTHR14255; CEREBLON; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR SMART; SM00464; LON; 1.
DR SUPFAM; SSF88697; PUA domain-like; 2.
DR PROSITE; PS51788; CULT; 1.
DR PROSITE; PS51787; LON_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 53..404
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
FT DOMAIN 405..512
FT /note="CULT"
FT /evidence="ECO:0000259|PROSITE:PS51788"
FT REGION 250..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 58276 MW; 777816E6DEEF0DB8 CRC64;
MLMEMEGLTL LRSLWSIHLL FPCKMTPTLS GYLLEAKIDG ARGKFAFLDG DRVLNLPMFY
LQVVLFPEAS LHLRVFQRRL VEAIDKAINH VDAPCMIGVV YVYRHTNDGH YTIASVGTMA
EIQKIQQLDD GSSCIFSHGQ QRFHLMRHWL DVDGVPWGEV QIIEEDTPQR TPRDAFGQLA
ATNSFRQCAS SIVPSLHASC STQLDHVGSD LDRDSLSPTS TSSDYSVTDK GIYLLGSQSS
GLVRCGVLDE SSNEGQNSIP EQSCQSHEPV KEIDGYSQPD KNTNTGDDDN LCFISSKSFQ
RARKKDTKQQ KHYFATKNAS QAPLSFWPRW AYEMYDSYSL SRRAADLWRQ VILNPSMDDH
VRKPNYLSFC IGSKLPISES LRQELLEIDG VSYRLQREIQ LLKAFNIVRC RNCLTHIARR
SDMVVTSSDS PMSSHSKPHR SVKEIITVYS ATGLALRGNP SKTHSWFPEY TWTIALCSAC
QSNIGWLFRA DNKNLHPRSF WAIRTSQISD DTQSR
//
