ID A0A1B6Q6D7_SORBI Unreviewed; 1118 AA.
AC A0A1B6Q6D7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=SORBI_3003G310900 {ECO:0000313|EMBL:KXG33467.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:KXG33467.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:KXG33467.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; CM000762; KXG33467.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B6Q6D7; -.
DR STRING; 4558.A0A1B6Q6D7; -.
DR EnsemblPlants; KXG33467; KXG33467; SORBI_3003G310900.
DR Gramene; KXG33467; KXG33467; SORBI_3003G310900.
DR InParanoid; A0A1B6Q6D7; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000000768; Chromosome 3.
DR ExpressionAtlas; A0A1B6Q6D7; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF934; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 62..187
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 207..530
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1118 AA; 130600 MW; B579A11BF8FD36C2 CRC64;
MAVSGAPEQP QREQPQQDHD EEMLVPHQDA IEGPQQDVVE GPQPMEESAS AVENQLVPDT
STSRFTWCIE NFSRRNVRKH YSDDFIVGGY KWRVLVFPRG NNGDHLSMYL DVADSNLLPP
GWSRNAQFSL AVVNQLDSKA SLRKEAIHQF NSRESDWGFT SFMPLLDLYD SSKGYVVNDK
CIIEAEVAVR KTFDFWNYDS KRMTGYVGLK NQGATCYMNS LLQTLYHIPY FRKAVYHMPT
TENDTPSGNI PLALQSLFYK LQHCDNSVAT KELTKSFGWD SYDSFMQHDV QELNRVLCEK
LENKMKGTPV EGAIQKLFEG HHMNYIECIN VDSKSTRKES FYDLALDVKG CSDVYASFDK
YVAQERLEGD NKYQSEEHGL QDAKKGMLFI DFPPVLQLQL KRFEYDFVRD TMLKINDRYE
FPLQLDLDRD DGKYLSPDAD RSVRNLYTLH SVLVHSGGVH GGHYYAFIRP KLSDQWYKFE
DERVTKEDMK RALEEQYGGE EELPHTNGLK NAPIRFTKHS NAYMLVYIRE SDKEKIICDL
DDEDIPDHLK VRLRKEQEEK ECKKKEKAEA HMFTALKVAR DSDFKEQIGR HMHFDLVDFD
KVNSFRAPKN MSINDVKEEL SKEFGIPVES QRFWVWAKRQ NFTYRPSRPL TFLEETSAIG
YLKDAIVAKL PNSEVRLFLE VHLGQENQGI ASGKTKEDIL IFFKLYDPEK EDLRYVGNFF
VKASGKPSDI VERLNEIAGF PSDEDIELYE EVKFEPAVMC VPIESNISFR SSQIDNGDII
CYQKRCLPDS MDRYRYPSVP SFFEYIHNRQ VVYFRLLDKP KEEGFSLELS KRSTYDDVVE
KVARQLRLDD PSKIRLTQHN LSSQQPKPHH IKYRSLNYLS DMLHNHNQMC NILYYDVLDI
PLPELESTRS LKITFENATN HEMSFHTMRL PKSNTLLDLI EDLKSKVELS CNDAEFRFFG
VHLHKICKVY QPGDKIDSVN EPLYIEEVPE EEKNAGPHDR LVHVYHFEDN RHVQYFGEPF
FFLIRDGEAL SDIKVRIQKR LQVPDEQFIK WKFAHVTFSR PEYLQDSDIV LNRFHKQKPV
YGAWEQHLGL EHTATTPRRS YFGSQNRHSF ERPVKIYN
//
