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Database: UniProt
Entry: A0A1B6QJZ5_SORBI
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ID   A0A1B6QJZ5_SORBI        Unreviewed;       618 AA.
AC   A0A1B6QJZ5;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   28-FEB-2018, entry version 10.
DE   RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN   ORFNames=SORBI_3001G201700 {ECO:0000313|EMBL:KXG38219.1};
OS   Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae;
OC   PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Sorghinae;
OC   Sorghum.
OX   NCBI_TaxID=4558 {ECO:0000313|EMBL:KXG38219.1, ECO:0000313|Proteomes:UP000000768};
RN   [1] {ECO:0000313|EMBL:KXG38219.1, ECO:0000313|Proteomes:UP000000768}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX   PubMed=19189423; DOI=10.1038/nature07723;
RA   Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA   Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A.,
RA   Schmutz J., Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K.,
RA   Chapman J., Feltus F.A., Gowik U., Grigoriev I.V., Lyons E.,
RA   Maher C.A., Martis M., Narechania A., Otillar R.P., Penning B.W.,
RA   Salamov A.A., Wang Y., Zhang L., Carpita N.C., Freeling M.,
RA   Gingle A.R., Hash C.T., Keller B., Klein P., Kresovich S.,
RA   McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman, Ware D.,
RA   Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT   "The Sorghum bicolor genome and the diversification of grasses.";
RL   Nature 457:551-556(2009).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003426}.
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DR   EMBL; CM000760; KXG38219.1; -; Genomic_DNA.
DR   EnsemblPlants; KXG38219; KXG38219; SORBI_3001G201700.
DR   Gramene; KXG38219; KXG38219; SORBI_3001G201700.
DR   Proteomes; UP000000768; Chromosome 1.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000768};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003426};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000768}.
FT   DOMAIN      118    298       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      308    574       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    141    141       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    212    212       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       283    283       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       284    284       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       307    307       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   618 AA;  67861 MW;  3F7E5F4C3AAFC5D2 CRC64;
     MISPAMWRSA ARRSSQVRRL LSSSAPPAPA GAAVPGPCIV HKRGNDILHD PWYNKDTAFP
     MTERDRLGLR GLLPPRVMSF EQQYERFINS FRSLEHNTRG EPDSIVALAK WRILNRLHDR
     NETLYYRVLI DNIKDFAPII YTPTVGLVCE NYSGLFRRPR GMYFSAKDKG EMMSMIYNWP
     AEKVDMIVVT DGSRILGLGD LGVQGIGIPI GKLDVYVAAA GINPQKVLPI MLDVGTNNQK
     LLEDKLYLGL RQPRLEGEEY LAVVDEFMEA VHARWPKAVV QFEDFQMKWA FETLQRYRNR
     FCMFNDDVQG TAGVALAGLL GAVRAQGRPL QDFTNQKIVV VGAGSAGIGV LSMAKQAMLR
     MPGIHRTGEG HNQFWVLDKD GLITKARKDL DSAVARFARG FGPDEVPDLH EGASLVEVVK
     KVKPHVLLGL SGVGGIFNEE VLKAMKESDS PRPAVFAMSN PTTKAECTPD DVFKHVGENA
     IFASGSPFSN VSLGNGKAGY ANQANNMYLF PGIGLGALLS GARHISDGML QAAAECLASY
     ITDDEIRKGI LFPSVSSIRH ITARVGAAVV RAAVAEDLAE GCCDVGPREL GSMSESESVD
     YVARKMWYPI YSPLVSDK
//
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