ID A0A1B6YAI6_9BACT Unreviewed; 804 AA.
AC A0A1B6YAI6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=A8B79_02420 {ECO:0000313|EMBL:OAN62426.1};
OS Balneola sp. EhC07.
OC Bacteria; Balneolota; Balneolia; Balneolales; Balneolaceae; Balneola.
OX NCBI_TaxID=1849360 {ECO:0000313|EMBL:OAN62426.1, ECO:0000313|Proteomes:UP000078514};
RN [1] {ECO:0000313|EMBL:OAN62426.1, ECO:0000313|Proteomes:UP000078514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EhC08 {ECO:0000313|EMBL:OAN62426.1,
RC ECO:0000313|Proteomes:UP000078514};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAN62426.1}.
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DR EMBL; LXYG01000014; OAN62426.1; -; Genomic_DNA.
DR RefSeq; WP_066219251.1; NZ_LXYG01000014.1.
DR AlphaFoldDB; A0A1B6YAI6; -.
DR STRING; 1849360.A8B79_02420; -.
DR REBASE; 159498; M2.BspC07ORF2410P.
DR InParanoid; A0A1B6YAI6; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000078514; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000078514};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..124
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 138..450
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 630..657
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 804 AA; 90881 MW; A5554A48CBFFF662 CRC64;
MPIKKSDLYA SIWKSCDELR GGMDASQYKD YVLSILFIKY VSDKYADAGE YAPIVIPDGS
SFQDMIKLKG QVDIGDQINK KIIAPLAEAN DLRGVIDQTD FNDDEKLGSG KEKVNRLSNL
IGIFQDANLD FGGNNAGDDD LLGDAYEYLM RNFATESGKS KGQFYTPAEV SRILANVIGV
EKADNPSLTA YDPTAGSGSL ILKVADEAPV DITIYGQEMD VATTALAKMN MVLHNRPEAV
HDIMRGNTLA DPKFSENGEL KRFDYVVANP PFSYKSWTNG LDPKNDLYNR FEGFGIPPTK
NGDYAFLLHI VKSLKNTGTA AVILPHGVLF RGNAEGKIRQ NLIERGYIKG IIGLPANLFY
GTGIPACILV LDKEQSGSRD GIFMIDGSEG YIKDGNKNRL RERDIHKIVD VFREQKAEGG
FSRFVPNDEI QKNEFNLNIP RYIDNSTEED IQDIEGHLKG GIPMRDVEGM NQFWDVYPGL
KDELFSPLRE GYLKLKTEKD VINEVIFSYP AFVSYSKELA KLFTEWKQAH YDSMKSIDED
VRPKALIAEI AEDLLKRYRD KALIDPYDIY QHLMNYWSET MRDDVYIIVE DGWTATLEPV
RNSKGNIKKG EFTCELIPKE LVINRYFPKE HQEIEQLKQQ QEEAAQVQEE LEQEHAVEGG
LLEEALSDAG NVTKGELTKR MKEIKGDEDF SDEFEVMKSY KTAYDNERKA KSSVKKAEKE
LDKQVIDKYK ELTEDEVQTL VVDDKWLPTI KFHIDGEVDA ISRSLTQRVN ELAGRYDKAV
VEIDKEADEL ETRVQSHLEA MGVV
//
