ID   A0A1B6Z879_9SPHN        Unreviewed;       438 AA.
AC   A0A1B6Z879;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE            EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN   ORFNames=A8B75_16005 {ECO:0000313|EMBL:OAO01271.1};
OS   Sphingomonadales bacterium EhC05.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales.
OX   NCBI_TaxID=1849171 {ECO:0000313|EMBL:OAO01271.1, ECO:0000313|Proteomes:UP000078455};
RN   [1] {ECO:0000313|Proteomes:UP000078455}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EhC05 {ECO:0000313|Proteomes:UP000078455};
RA   Rosana A., Orata F., Boucher Y., Case R.;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00001526};
CC   -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC       {ECO:0000256|ARBA:ARBA00009009}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAO01271.1}.
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DR   EMBL; LXYP01000026; OAO01271.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B6Z879; -.
DR   STRING; 1849171.A8B75_16005; -.
DR   Proteomes; UP000078455; Unassembled WGS sequence.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR   GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR045155; Beta-lactam_cat.
DR   InterPro; IPR000871; Beta-lactam_class-A.
DR   PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR   PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13354; Beta-lactamase2; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078455};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..438
FT                   /note="beta-lactamase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008592153"
FT   DOMAIN          171..267
FT                   /note="Beta-lactamase class A catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF13354"
SQ   SEQUENCE   438 AA;  48147 MW;  C2BC5A252AF933DD CRC64;
     MPKRLRRFCF SLSLAILSCA IVSNQAFALP TSLISSQYHM RSTELLEILQ GSQREEQFFA
     QSFRDAIPVT QFRNLLAELN RQYGQAVGVK SITATSDYDG TIEVLYEKAV ISIKMVIDRD
     APYPVIGLLV TGAWVYNDNL ADITREMADL PGVSGFQIAE LTSATMRPVE DRNANRQFAI
     GSVFKLYILA ELGRSIAAGE RKWGDIIPLT HKSLPSGILQ KWPDRSPLTL HSLATLMISI
     SDNSAADILI AELGRENIGN LLRLTGHSDP ARTLPLLSTL EAFALKMEDN RDLRQAYIGS
     SETEQAALLA RQKARLGLNS VSIANLATNP RHIDRIEWYA APADVNKLLL YLNQSQDPTI
     RNILAVNPII SPGDALRWRY LGGKGGSEPG VISFAFIAKA QSGMTYAVSG SWNNATAPVD
     NQKFLSLVSR MLNQLAGQ
//