ID A0A1B7N8E1_9AGAM Unreviewed; 1267 AA.
AC A0A1B7N8E1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:OAX41110.1};
GN ORFNames=K503DRAFT_848613 {ECO:0000313|EMBL:OAX41110.1};
OS Rhizopogon vinicolor AM-OR11-026.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Suillineae; Rhizopogonaceae; Rhizopogon.
OX NCBI_TaxID=1314800 {ECO:0000313|EMBL:OAX41110.1, ECO:0000313|Proteomes:UP000092154};
RN [1] {ECO:0000313|EMBL:OAX41110.1, ECO:0000313|Proteomes:UP000092154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM-OR11-026 {ECO:0000313|EMBL:OAX41110.1,
RC ECO:0000313|Proteomes:UP000092154};
RG DOE Joint Genome Institute;
RA Mujic A.B., Kuo A., Tritt A., Lipzen A., Chen C., Johnson J., Sharma A.,
RA Barry K., Grigoriev I.V., Spatafora J.W.;
RT "Comparative genomics of the ectomycorrhizal sister species Rhizopogon
RT vinicolor and Rhizopogon vesiculosus (Basidiomycota: Boletales) reveals a
RT divergence of the mating type B locus.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV448190; OAX41110.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B7N8E1; -.
DR STRING; 1314800.A0A1B7N8E1; -.
DR InParanoid; A0A1B7N8E1; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000092154; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000092154};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 38..97
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 226..260
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 860..991
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1023..1259
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 288..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 142567 MW; 689067BA1D125238 CRC64;
MAANGLTMCS DMNNFPSQPT SVTAEQEHML QLPEEQYITT FFCRARYDYQ AKDTSFLSFH
KNEVIEVITQ LESGWWDGFL GDKRGWFPSN YVTVIYDEEI AEIPPSNYDL LTQQEPLQHI
HEVTHDNSNT RNTLPNGFLE SCSDSVTFSS DFWMPEVTHD GQIYYLNTQT GQHSRYLPVQ
ADEVSLGGLG GLASFLQGSP SSTGAESGLR VLTEPSITSF GIPKRSGTPE PWVKRLTDDG
MSYYYWNKLT DQMSWTIPET KGAGKMDRNN VLAESSYLFS SPDEELAPMR LRSDSGTSQR
YVRDRNHSKL EHVSDSDDSG LYYPGHVDSP SASGCSHSDQ DLFADQTADM RPSVELTAIE
TFAKSLQQSL SPSPPELISE LSHITHDAIA AVIQKNESLV SVSRGTEHGQ LDTLIRAVVT
AVRNLLCICA PLIHMPYIID GHRPKATASQ ALLKPAERKV IATLSGLVLS VRAMEYDSDP
AAHKTASRIG SDAEKLDHAI MTFVFEVQRC QNEQLFGVGT KRVQGYFPPD YLGLGLVGAG
NWTGFGWVTQ DDGAEAPQRI LDGAVFSEFT THMVSMQAMF ETFHNAFKSM GDERQQRVWN
AGREFLSRLS SLLLFVGNIH IARHVDIDGV YSDTADAERA TLYSETVDRA RLLVRRLEAV
VQALYDDAAT LLLTMQQVHH PTHRASRQDR DLQYEYLDKL RMSQLSIIDS HFDTLPMSLI
DPAGPKSKDI VDTEAVFGAS DIEKIEKPGT ILSDQVPIRS QSQLPGTTIT HMDQPFMTAA
SSHDPTMSAH ILVPSPSEKS QDVISSSNSI SMLDDEITRA ATNARKIKKI LGDDPPEHII
STKPWYLRPD YTKNDIIIDV DGSVRAGTVP ALVERLTSHD SSDPTFIRTF LMTYKSFTTL
DELFDHLVHR FFIRTPDELS LAEAEEWRKL KQHIIQMRVL NTFKTIVSHE GFLDKEDVFI
LNRMKEFLQN EEVGKIAAAK QLLSLVVERA RGGCIKKGLT SLGKQPPSIM PKPNTKLNLL
DIDALELARQ LTIMESHLYQ KIRPVECLQR SREQKADHKD NITRIIQTSN RIANWVAGSV
LSQEDYKKRA IILKQFISVA DRCRSMHNYS SMAAIVCGLT LPPIWRLKRS WEQVGARHMA
QFGTCEMTTI NSSKNFSNYR SMLATVSPPC VPFIGVFLTT LTFIQVGSKD TLPGNLVNFR
KRQKASEVIQ DIQRWQTFPH NFHPIKSVQT YLEDSLTKFR EQVGAGDYFW NLSLEREPQD
ERMTRIF
//
