ID A0A1B7NQ92_9EURO Unreviewed; 666 AA.
AC A0A1B7NQ92;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
DE Flags: Fragment;
GN ORFNames=ACJ72_06691 {ECO:0000313|EMBL:OAX78993.1};
OS Emergomyces africanus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emergomyces.
OX NCBI_TaxID=1955775 {ECO:0000313|EMBL:OAX78993.1, ECO:0000313|Proteomes:UP000091918};
RN [1] {ECO:0000313|EMBL:OAX78993.1, ECO:0000313|Proteomes:UP000091918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 136260 {ECO:0000313|EMBL:OAX78993.1,
RC ECO:0000313|Proteomes:UP000091918};
RA Cuomo C.A., Schwartz I.S., Kenyon C., de Hoog G.S., Govender N.P.,
RA Botha A., Moreno L., de Vries M., Munoz J.F., Stielow J.B.;
RT "Emmonsia species relationships and genome sequence.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAX78993.1}.
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DR EMBL; LGUA01001207; OAX78993.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B7NQ92; -.
DR STRING; 1658172.A0A1B7NQ92; -.
DR OrthoDB; 118994at2759; -.
DR Proteomes; UP000091918; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000091918}.
FT DOMAIN 77..216
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 258..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 666
FT /evidence="ECO:0000313|EMBL:OAX78993.1"
SQ SEQUENCE 666 AA; 74363 MW; 2ACB6243988CEFCF CRC64;
MADKGWNFPR GSDDELGYED HPWEWIYEED QASIKGSGLN ASDDEIDCVT PTKRKASQRA
RRKAPPRKII GAKMGSFECR LGQAVLLKSP EPGKDWAGII CEFVEEEDDD EGEDGSGKLV
KSANIMWFAS PDEFLATKHK KREDALHNEQ YITMDFNVNP LTSIDGKATV LSKAAFEQRY
PKGLPPKGKT ALAEFNKCII CRRGVNQLQG KYTEEFVWED IFDGTEQGLF ELIDFIKAGL
KRSRKRKVVD DEYAGVKEHG SVPATPRKRH KTASVTGTPK SQRRQKVLTT PTHRRIVVKK
PVEFTPLGTR ILSPSHFTSS PYRLARNLLH VSSVPASLPC RDTEFYTVYN SLRIAITDGT
GTCIYISGPP GTGKTATVRE VIAQRNASVL AEELDDFVFV EINGMKVTDP HQSYSLLWEA
LKGDRVSPSH ALDLLEREFS HPSPRRVPCV VLMDELDQLV TKNQSVMYNF FNWPALRYSH
LIVLAVANTM DLPERTLSNK ISSRLGLTRI TFSGYKHQEL MEIIGSRLSN VPGNIVDPDA
VQFASRKVAA VSGDARRALD ICRRAVEIAE QVSEKAEKTK LKHALSLSNG NGMDMDDMDT
SFLPPTPSKS ISRRNRVTGP SNKKFLQTSE TDSEPLPRVT IATIKQAIQE ATSTPLQQSL
RCLPLT
//
