ID A0A1B7TA07_9ASCO Unreviewed; 3169 AA.
AC A0A1B7TA07;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=HANVADRAFT_53825 {ECO:0000313|EMBL:OBA25579.1};
OS Hanseniaspora valbyensis NRRL Y-1626.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=766949 {ECO:0000313|EMBL:OBA25579.1, ECO:0000313|Proteomes:UP000092321};
RN [1] {ECO:0000313|Proteomes:UP000092321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1626 {ECO:0000313|Proteomes:UP000092321};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA25579.1}.
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DR EMBL; LXPE01000069; OBA25579.1; -; Genomic_DNA.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000092321; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092321}.
FT DOMAIN 1791..1980
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 93..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3169 AA; 362035 MW; EB4DF24269B5A103 CRC64;
MHASDYNSFT NTPTTYSRHL LKCISKFLPN NPNFCPSVKE IEEEEYYQKC VKNLLLLCMD
NDTTVLIDNI LKLLKDKLSK YEEFPIVQED TDINDTLSNT SNHTSKVSSP NFGSECKTPS
RNGSPLVNPH TNPSSKDFYS LEKNVSPSAS LPNINLHSEG NNNNSNKKNS SSDNLNRQTH
SSGSSDTTDH NNNESHLSEA TMRLMDKYTN IRKSTKYPIR SLGIYNYVLI FLRLMIEIFE
VGYLFRDCNT FSDLSTIEKR KELEKSFHLF YANNNTAFKL LKFGISRPNA NDTNNLKKDI
NSSNRTRPQK LPYKTFRKLL RFLIAIKSSV KLDDCVAKIV KEDQLLLPNM KALIFKSLKT
SSIHVASNGN FLNHDDAKLD TIPHLKEARD MVDVNVEYIL SFLANSNSQD YMHFLEQIMI
VNPGPEAFKD KFVLQELKEK YVKHNEFDEI DTERFINEEL NNNDNYSLNT AFSSSSNASN
GEGNTRYILI PAYLSLFTSD LLFSTEYISF TSFQNIKDLT VFIQFIHKLH KTYKRSIFRK
CILLSFAHSL KIFMASKSAD YLKYTHNNNT PQSTILKKEL TSLFNSVYGS FDTLRLINDI
YGNSTGTTIN YKSSKFNSSG GGDDETSEEG GFDDERQNVN MSPSSKHSER NNLNVTTSSS
SSTILSFKDA TPDKGTSSND SKISPSKESI NEMMQLLNSV SKNGLVLSDA GDAYHFGTCN
IEDELLNPGD IAVTRSLTMI SLFNVDVFAN YLNKSDIKGL DNVEKSDSSS NSSPTDSKNY
KPISSFVKNL KVKSDSSDRI SLNSSNSEQT NSSMGPSSPS SSSFISAHLE SQTKNVGSAI
KNNLFKMSKL PNYYSTNKEN KFWSSLMKHF CTSQALEISD RSNLTIFSVL LHVYLMCGFL
NIHDSSSPII KFAKRLSSSF GSIFQLNDTD DLPKNLAYAQ RVLNRNLPSK TKAVVENIIS
SLLLFPEATA ETLGRKCDIV TTNQEFGVNI HYELYCISEG MKFFFYIPNP YKEKYGIYNK
IVEVIKRMTF HISGKLIKSL PYLDDNASEI IDDIIFERYK PEEHDIYYFI GKRNHNVLRK
FFENDSIETI TPQEYQDMLG YKKSIELSLI ETNTFINNKY SENSTYKPNI NFVNIGSSQE
SKLSDFLAAS LISNTVNILK RCSGLATDEN IAEALTMHLE YTEKILLSGV LNSNEKLVKE
CVSCYDIIAQ TSIPETNYKV FRAFYQTSGK TAFLLSVASF NLSVPGITRL TMLQVLERVL
KFRKNFYKFV FVDSENSINE HETSVFDSLH QALFRTILIN LSFNDVKAHE TLRSLCFLYT
AEVDFYCSYK KKNIEDIDSC YYDFAQSIAN CNNVFGPIAF QRHIRADILK YIDRPSRALF
DCFMVLCDKV FDMCIVGQNS LLRDDQTRFR NYCGILASFI GVFKINFLSS RGANNSLDKY
ELLISKKIDF FIERQCELLN SSDLLTRENS KDILSTELHP GVFNILFEKL VQRLDMFVEI
CKTGEIERNF FLLEQILAVL RSILERDEIS FIILCTKSVL DIIQKVLNII ALMDYETHYK
YKVIIHTSKA ILSFKHAENV LFLKGAYSLK NYWLQTIFSW FSDVAFVDLD LINLTKAHRE
MDLEKRDIDY LRLDTSIECV KALAFLTDKI SLEAPAATTA DDLKISKRSA FSNYFNILLK
SLERTSDHEN VPFVLRHKTL MLNENVLSCL TNLLCSNPDI GLDFVLPIAF TGNSIIRRTL
LDVLIELTKN ANKDRSVLAI DQEEALNDII KQTEICPQIL TGLASQASVN EVERLATSFL
KICAPKKITH IFIAELVDDE IAKASRYMDI LRRNSLATRS LAIFSRLKGY DFLNKTVRPL
ILDITIEGLD FEIEKPIADD AERELQITRF VNCMDTFCEN VLNAFDDLPA EFFYISQRIY
DAANKKFPGS ELISVGSFLF LRFFCPAIIN PETDSINNRI SSKNRRTLIL VAKVLQNLAN
KTINTLKWPL LEDQQQKLDE WSEKMFHFLE KVSDKKNLTP IPVDYSAPIE KLENLGTVHK
LLYSRYVAIR VSMIKDVKDA KSFNELIESS RVVDKAMLQL GQPALELNND IPKIIKENSE
KYSLAYDFMN RYYLKVGSMP EISGLIFVSA DSDGVPRITL SLKLMEMDSV DVNEVVYKLI
FLESGLWSKK FNILLDGTAT SRCSEKLERI MGLFMNLLPR DSFINLDTVI FYNVNEAFLV
FWWNQAKKAY ESFGLGTLKH IFLTSNCSSE VFKSMQLQKY SVDIYNDVRV TLYNTSYYEE
AKHRFVPVTL KIGNNHIQVV RETPKRIKFS ENEEVCECHF NDIYFIKNMV SAYASNTIGI
PYEFTISFKD GTNLILSTHK YLEILKLLYY ATTKLKEEAK FGGPVDTTIK KENTNESELN
TLAKILLVIL SALSSNDDFI KSRAFALLAV TQSTFNVDIG HNIFPTTEIS LPADNLVLVK
SITKKLTKTK PELTYFILKQ CFEGIFSGKL LVNNVQLLTL TSYWVENVHE YIYLDVDNNG
KDRTIAILRL LIKCTLDDID LMYSFKIFLW SKLMLVPDLL ELITDEVITH AMDRESEGFD
WSPCISILSM IPSVSVSGIV IQRLLKLINK LIPTLTNDNN VNSWSEVIIL VSILQELSFD
SCVSFEGFVP EVLYIISMLI DVRPIKIKTS LLKILINICN SFISATGDDY EKRQNFNNCI
DILTSARAKY VFGLSRENSN SYYSTTAAVL LSKVSYMSEL INYMLLIMQI INKDASDEIL
WKAKYKDLIL EAIFGEESYI SARAMMYLSI LCRDGVYEDL MKNLFTITSK VLADISNTEE
TMLHLVTHVV SYGNFVSGIN NNNPRLLFQV CWLCHSFLMS PNLVVYHAGL VAMTSCLKRI
LRLANDTNVR INDAIWEDNR QGLGDCLREL EIVDKRVNTS KNFMFTHVHC ISKAALVSHT
KVYGTDFLKM LLLVTLKEDG DHLETSTDYH CYMFLYFLLQ STEEFDELHR ELNKGKSPTY
EFINKDFEMP DFLFAWLNNP KDDTKNLVLY QVSLLVSIDT IPEITKLKLL CISLHMAENH
PLVFFEFMSN VIEEAAKCEE RATMFELVSK SFEVSNITIT SPYYHQLGEL ENRMDQRLKN
MNLEALSDLK SFKNGATGFV NDERSAIITM KRKRCLLKIL DKIINDDYS
//
