ID A0A1B7TBD5_9ASCO Unreviewed; 985 AA.
AC A0A1B7TBD5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=RhoGAP-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HANVADRAFT_41035 {ECO:0000313|EMBL:OBA26056.1};
OS Hanseniaspora valbyensis NRRL Y-1626.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=766949 {ECO:0000313|EMBL:OBA26056.1, ECO:0000313|Proteomes:UP000092321};
RN [1] {ECO:0000313|Proteomes:UP000092321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1626 {ECO:0000313|Proteomes:UP000092321};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA26056.1}.
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DR EMBL; LXPE01000025; OBA26056.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B7TBD5; -.
DR OrthoDB; 1329523at2759; -.
DR Proteomes; UP000092321; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF1; RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000092321};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 44..114
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 484..548
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 759..950
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 382..409
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 343..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 985 AA; 113040 MW; 892C109EFE16ADD7 CRC64;
MNNQEEEEDG GGIEKNGREE TINKNSSTSL LLSAPATNVE LTPKHCGTCN NIIEEHAVKA
LGKIYHQDCF KCYDCGNVCR PKYFPFTIRE EGKDESESKQ VPLCQNDYFK RNKLICDVCH
NLLKGTYYNA FGRLYDEEHF SCSICKETCS LQECFNFEGS LYCKYHYLKL YSKKCKGCEY
PITDQHFEFE RSGKIYRWHP ECYGIHRYWH IDLCPSNLAL PDFVLSTAEE SKLETTNVKE
EAKRNLENNI SISSDFTYKT WSILYKFEEE AAGCISDMLQ FLTHEDKTKG VEAAALLVLK
VNCLFKAIDS IQVVSGGLNL DRDLAKDLEF TNINEQNEKK TSDNSSDGQQ QSINETTNTK
YKKYPKSFSS RVMMYLQLLR KYDINEFENE NLKKKNDSLN EEGSDGESNE EDETSLSKAM
SIINALSHYL KLLIKFGIYN ALEYNKSAHS TNALSKFLRE VNKSSQFSET PFNFIKDVAI
DSTDSCEGCH KYIQQECIVY KNKRWHINCL RCDKCQKLIE RYDILDANFN RRTQKVLCPL
CSTSDPNAEP GFTPTTRLSH LTYLLKIALV KTRALVMIKM QNQRISNEMR TNSMMKEQLY
IKTLNDIKTL RSKRNSLKIK SSAEKNSLDT SKKRVVSHSK ETISQFSNSK TLTLDDISRI
VAMEQSRGAK DEHGFKHFNK FENKDDEESS SSDIFYTDLS LDHLYRIQLI SLSILLSQAE
ELENIDSILA LLKKSAQPVI ISPNVGTKFW KNPQQVFGVP LEQLTEYYGI DSDLSLGSTR
IKIPLLLDEL ISSLKQLDLS MEGLFRINGN IKKLRLLTEE MNANPTNPPD FSGENAIQLA
ALLKKFFREL PEPLLTTTYC KLWLNCLGND ENMKLVYCLL PKYHRNCCEV LFSFLKYVST
FASGSKMDVY NLATVFSPNI LYSSKDTIHE YSGLSIKVVE HLINLNEDMV LVPDYLMLLL
KDTIDAKLPT DFAVINDYVK LKNTK
//
