ID A0A1B7TBK7_9ASCO Unreviewed; 1044 AA.
AC A0A1B7TBK7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Exosome complex exonuclease RRP44 {ECO:0000313|EMBL:OBA26097.1};
GN ORFNames=HANVADRAFT_33660 {ECO:0000313|EMBL:OBA26097.1};
OS Hanseniaspora valbyensis NRRL Y-1626.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=766949 {ECO:0000313|EMBL:OBA26097.1, ECO:0000313|Proteomes:UP000092321};
RN [1] {ECO:0000313|Proteomes:UP000092321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1626 {ECO:0000313|Proteomes:UP000092321};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA26097.1}.
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DR EMBL; LXPE01000024; OBA26097.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B7TBK7; -.
DR OrthoDB; 945235at2759; -.
DR Proteomes; UP000092321; Unassembled WGS sequence.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:OBA26097.1};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:OBA26097.1};
KW Nuclease {ECO:0000313|EMBL:OBA26097.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000092321};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 104..230
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT DOMAIN 567..902
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 357..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 118492 MW; FFF301F5A99FDBEB CRC64;
MSINLESTVP VIGKKRVINN IDTNEDDLNI KQQKLTVTTK YFIKNSNNNS NITPQPVKIL
REHYLRNDIP CYFSDCSKCT YDANNHANLN NSDEILIKNK KAPHLVILDT NIIINCIDLI
ESEKCFNNVI IPQTAIDELK NLSFPIYKRL KSLIGSTELS DSNTKTKNIA VFYNEFMNKT
FVDRLTNETI NDRNDRAIRK LAKYYNYHLN KKQNLNIDVI LLTNDKLNLA KCKETEITAM
NISNYIKQLP NGEELIDLIP QDDVTADNKQ KDSGSNSEDG NIYDEYYSGS RISAGLKNGS
IYQGIIQISE HNFLQGFVNV PSFPKPILIK GLQNLNRSFN SDIVAIELLP KEQWQQESSY
QVDSEHYDVN ANPDDGAGDD DATNDMAYNE DQQKIVISDK QRRLLAQEAI NQSKNNKNCV
PTGKVVGIIR RSWRQYVGQI VETSVNEEAN TSTSSQSCFV LLMDLKLPRV VIKTRRAVEL
LNKRILIAVD SWPRDRRYPL GHLIKDLGVV ESKEAETEAL LLEHDVEYRP FSKKVVQCLP
EEGENWKCPV DLKDPAELAK DPLLANRVDL RDKLVCSIDP PGCVDIDDAL HCKVLPNGNY
EVGVHIADVT HFVKPNTPLD VEGAARGTSV YLVDKRIDML PMLLGTNLCS LKPYVDRYSF
SVIWELDSKA NIVNVNCMKS CIKSREAFAY EEAQMRIDDK SQNDELTIGM RNLLKLSKLL
KQKRLDAGAL NLASPEVKVH MDSETADAND VEIKKTFETN SLVEEFMLLA NISVARKIQD
AYPQTAMLRR HGAPPRTNFE ILNDMLAKLK NPDFQISLDS SKALANSLDN IEDPEDSFFN
TLVRILSTRC MMAAEYFPSG AHPYADYRHY GLAVDIYTHF TSPIRRYCDI VAHRQLAGAI
GYEMLDLSHR DKNKMDLICK NINKRHRNAQ FAGRASIEYY VGQVMKNSDK SSTPKVETGY
IIKIFHNGIQ VLVPKFGVEG LIRLENMCND LNGVEFEEQE YKLTFKSNVD GKNRSVKVFD
KVDVEVNSIL DPVTNKRKAQ LLLK
//
