ID A0A1B7TC40_9ASCO Unreviewed; 571 AA.
AC A0A1B7TC40;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN ORFNames=HANVADRAFT_53267 {ECO:0000313|EMBL:OBA26290.1};
OS Hanseniaspora valbyensis NRRL Y-1626.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=766949 {ECO:0000313|EMBL:OBA26290.1, ECO:0000313|Proteomes:UP000092321};
RN [1] {ECO:0000313|Proteomes:UP000092321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1626 {ECO:0000313|Proteomes:UP000092321};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA26290.1}.
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DR EMBL; LXPE01000020; OBA26290.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B7TC40; -.
DR OrthoDB; 1826981at2759; -.
DR Proteomes; UP000092321; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF33; LYSOPHOSPHOLIPASE 1-RELATED; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000092321};
KW Signal {ECO:0000256|RuleBase:RU362103}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT CHAIN 22..571
FT /note="Lysophospholipase"
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT /id="PRO_5008447692"
FT DOMAIN 32..571
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
SQ SEQUENCE 571 AA; 62375 MW; 7A8D4BF69B390D52 CRC64;
MQYSSSLITA LLLLASNSVS AATSAYQPEV VSCPSNSSSL VRTSGGLSTD ETEWVTKRDA
ITEPILKSYL SSQLNSTSTL DKIFSDDNDQ KPKIAFAVSG GSYRAMLSGA GMLSAFDNRT
DDNTGSGKLG GLLQASTYLA GLSGGNWLTT SLAFNDWISV QEVVDQVKNS NGSSLWNITN
SILAPFGAEE PMNDLLRWAK IRTDIQNKED AGFPVSIVDL WGLALSYQFF ENGAENLIWS
SLQKSDVFAN AEMPFIISTA EQYNAVETIN TTIFEFNPFE FGSWEHEKFA NIEYLGTSFK
DGSPVNSTQC VNNFDNAGYI LGTSAGLFNL VAEKIDSLGL TGTTKEILEI LISSWASENG
IPAAYPNPFY GLEAESNDFG SNITYLEDLY LVDGGEDGET LPFVPLLQEE REIDAIFAFD
IDANTDELWP SGLSLYATYA RQAQPIGADI AFPFVPNTTV FVEESLNEKT VFFGCNATLL
SELAYIPPLV VYIPNKEYTF ASNTSTFQLS YTDKEKLGMI ENGYAAAYQN NTDSDYATCI
SCAVILRAQQ RLDITPSAEC QSCFDNYCWS P
//
