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Database: UniProt
Entry: A0A1B7TDH4_9ASCO
LinkDB: A0A1B7TDH4_9ASCO
Original site: A0A1B7TDH4_9ASCO 
ID   A0A1B7TDH4_9ASCO        Unreviewed;      1076 AA.
AC   A0A1B7TDH4;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   08-MAY-2019, entry version 15.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=HANVADRAFT_24533 {ECO:0000313|EMBL:OBA26809.1};
OS   Hanseniaspora valbyensis NRRL Y-1626.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX   NCBI_TaxID=766949 {ECO:0000313|EMBL:OBA26809.1};
RN   [1] {ECO:0000313|EMBL:OBA26809.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL Y-1626 {ECO:0000313|EMBL:OBA26809.1};
RG   DOE Joint Genome Institute;
RA   Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T.,
RA   Goker M., Salamov A., Wisecaver J., Long T.M., Aerts A.L., Barry K.,
RA   Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA   Hanson S.J., Klenk H.-P., Labutti K., Lapidus A., Lindquist E.,
RA   Lipzen A., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.,
RA   Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA   Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA   Jeffries T.W.;
RT   "Comparative genomics of biotechnologically important yeasts.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OBA26809.1}.
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DR   EMBL; LXPE01000013; OBA26809.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      107    460       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      524    951       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      987   1059       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1076 AA;  122409 MW;  22EDB4E4A0CBEC24 CRC64;
     MSEPISKDIK SINLNNILND NTQYTKHISH GYKNSQGKSL QNNEKADSEV LESLELSNTV
     VKQIWSRKQI NPNDLNNKHL GDINFQQIDA QEFYHNNESA IRFYGVTDKG YSIICNVLNF
     QHYFYIPSPY GNLNNNQIEL ATNLETLKNH LNENFLQDPT SGKVTLIEQC YKHNIWGYQG
     DSKLPFLKIY FNNHSSIFKI RKQFEDGNVE IPGRFHYGER LTSFDNIAYL LRCMIDLGIV
     GMSWLTLPEN AYTLVDPNKR VSRCQIELDI DYKSLIVHSA DDHEWSKFAP LRILSFDLEC
     SGRPGVFPEP QIDPVIQIAN VVNVQGSTSG HPSIKNVFTV KSCSPISGVE IFSYEEEKDM
     LLGWKDFVNE VDPDILIGYN IEGFDLPYLL DRAESLKLVT FPYFGRMKFI KNNYKVSTFT
     SKALGTRDNK IINISGRLQL DILAFIRREY KLRSYTLNAV SAHFLGEQKE DVHYSIITDL
     QNGDADTRRR LAIYCLKDAL LPLKLLEKLM PLINYTEMSR VTGVPFTYLL TRGQQIKVIS
     QIFRKCLTID TLVPNLLGGN GSDEQYEGAT VIEPIRGFYN MPIATLDFNS LYPSIIMAHN
     LCYTTLLDNA SIERLKLVKD EDYIITPNGD AFVKEHKKKG ILPEILDELI KARKRAKNQL
     KSEKDPFRKK VLDGKQLALK ISANSVYGFT GATVGKLPCL QISSSVTAFG REMILKTKKH
     VEGNYNIKNG YKHNAVVVYG DTDSVMIKFG TDDLKESMAL GDQAAKEISK IFKDPINLEF
     EKCYFPYLLI NKKRYAGLYW TNPDKYDKLD QKGLASVRRD SCPLVSLVMN KMLKNILIDR
     DVEKGLEYLD TVIKSVLKNN IDISKLIISK ALAPNYTNPQ PHAILAQKIA KREGSGPQVG
     DRVDYVIVGG NTKLYERAED PLYVLENNIP IDSKYYLNQQ LKNPIVSIIG PIIGEQKAIG
     KFNITEITIT TGKTGALMGF LKKVRTCQSC KNPIKKGVTG PLCDNCASKT DTIYLNKLVE
     VRDLQEKFNQ LWTKCQRCSG SLHNEVLCSN KNCDIFYMRI KTRNTLQDKL ESISQW
//
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