ID A0A1B7TK59_9ASCO Unreviewed; 736 AA.
AC A0A1B7TK59;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ATP-dependent metallopeptidase Hfl {ECO:0000313|EMBL:OBA29025.1};
GN ORFNames=HANVADRAFT_20636 {ECO:0000313|EMBL:OBA29025.1};
OS Hanseniaspora valbyensis NRRL Y-1626.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycodaceae; Hanseniaspora.
OX NCBI_TaxID=766949 {ECO:0000313|EMBL:OBA29025.1, ECO:0000313|Proteomes:UP000092321};
RN [1] {ECO:0000313|Proteomes:UP000092321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-1626 {ECO:0000313|Proteomes:UP000092321};
RX PubMed=27535936; DOI=10.1073/pnas.1603941113;
RA Riley R., Haridas S., Wolfe K.H., Lopes M.R., Hittinger C.T., Goeker M.,
RA Salamov A.A., Wisecaver J.H., Long T.M., Calvey C.H., Aerts A.L.,
RA Barry K.W., Choi C., Clum A., Coughlan A.Y., Deshpande S., Douglass A.P.,
RA Hanson S.J., Klenk H.-P., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lipzen A.M., Meier-Kolthoff J.P., Ohm R.A., Otillar R.P., Pangilinan J.L.,
RA Peng Y., Rokas A., Rosa C.A., Scheuner C., Sibirny A.A., Slot J.C.,
RA Stielow J.B., Sun H., Kurtzman C.P., Blackwell M., Grigoriev I.V.,
RA Jeffries T.W.;
RT "Comparative genomics of biotechnologically important yeasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:9882-9887(2016).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBA29025.1}.
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DR EMBL; LXPE01000001; OBA29025.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B7TK59; -.
DR OrthoDB; 9585at2759; -.
DR Proteomes; UP000092321; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR InterPro; IPR048438; Yme1-like_N.
DR PANTHER; PTHR23076:SF37; ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1; 1.
DR PANTHER; PTHR23076; METALLOPROTEASE M41 FTSH; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR Pfam; PF21232; Yme1-like_N; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000092321}.
FT DOMAIN 308..444
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 717..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 80626 MW; 165B4B92E38A5372 CRC64;
MNILKNNTKY VSLLNNSAIR TNNRLSFSTY PIKFNQKNGI NKPEEQIKPS AKTEPSIPKI
TAEPKEEATQ QQPVEPILTE NKETVKEEPV THELLAIKEQ EANRSLSDSA VQADFYKLLL
KSGYAQYVIS RYETPGIATS PECMGLYMEA LTTVGRHVEA TNVRQAILGN NSGSNAAGAS
GSAAASANGS GQPMNNGGAP FVNPMFGTAK EPMHVILTES TFTMVFRVIK YVVTLGLTLY
LLNEGFKFVT ENSTLFKNNE VSDNAIDTSK ANVKFEDVAG VDEARAELEE IVDFLRDPAK
YEALGGKLPK GVLLTGPPGT GKTLLARATA GEAGVDFFFM SGSEFDEVYV GVGAKRIRDL
FKQARARAPA IIFIDELDAI GGKRNPKDQA YAKQTLNQLL VELDGFEQTQ GIIVIGATNF
PESLDKALTR PGRFDKMVTV SLPDIRGRAA ILKQHIKKIT TAKDVNIENI AKGTTGFSGA
QLASLINQAA VYACQQNANA VNMSHMEWAK DKILLGAEKK SMVLSEATRK ATAYHEAGHA
IMALYTKYTE PLYKATILPR GNALGVTYQL PEADKYDITK AECLARLDVC MGGKAAEEVI
FGKEHTTSGC GSDLRSATKM ARNVVTSYGM NEKVGPVELT EDWNMWSGKV KDMADQEVIQ
LLKESEERSR QLLKSKDKEF RRLAEALIDY ETLDRAEMDK VIKGEPLDKP KYRTNIVVDS
PESDGRKQID PITASI
//
