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Database: UniProt
Entry: A0A1B7XH18_9DELT
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ID   A0A1B7XH18_9DELT        Unreviewed;       422 AA.
AC   A0A1B7XH18;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   16-JAN-2019, entry version 12.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=SP90_04850 {ECO:0000313|EMBL:OBQ54817.1};
OS   Halodesulfovibrio spirochaetisodalis.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Halodesulfovibrio.
OX   NCBI_TaxID=1560234 {ECO:0000313|EMBL:OBQ54817.1, ECO:0000313|Proteomes:UP000091979};
RN   [1] {ECO:0000313|EMBL:OBQ54817.1, ECO:0000313|Proteomes:UP000091979}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC271 {ECO:0000313|EMBL:OBQ54817.1,
RC   ECO:0000313|Proteomes:UP000091979};
RA   Shivani Y., Subhash Y., Sasikala C., Ramana C.V.;
RT   "Desulfovibrio sp. JC271 draft genome sequence.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OBQ54817.1}.
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DR   EMBL; JXMS01000006; OBQ54817.1; -; Genomic_DNA.
DR   RefSeq; WP_066853164.1; NZ_JXMS01000006.1.
DR   EnsemblBacteria; OBQ54817; OBQ54817; SP90_04850.
DR   PATRIC; fig|1560234.3.peg.2930; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000091979; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000091979};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:OBQ54817.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091979}.
FT   DOMAIN      107    313       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   422 AA;  44665 MW;  1EA93ADEC5E6ED44 CRC64;
     MRILIVGSGG REHALAWKLR QSAKVEEIFI APGNGGTALE GTNVPIKADD LPALVAFAKE
     QAIDLVVPGP ELPLVLGIKD ALDLEGIPCF GPNAFAAQLE GSKAFAKNIM QEAGVPTAAF
     GVFEDFSEAR NFVLEKGAPI VVKADGLAAG KGVIVAQSTD EAIQALEEIM VQKSFGDSGK
     HVVVEECLVG EEASFICFCD GNTVKPLPSS QDHKAVYDGD TGPNTGGMGA YSPAPVLPDS
     RYDEIIESVM KPVVNLLGKK DKPFIGILYA GIMMTENGPY VLEFNVRFGD PECQPLLMRL
     DCDLADVMMA CVQGKLAETP LPIKKETTLG VVVAADGYPG SYPKGMGITG FAEAEALGDV
     KVFQAGTTIE NGQTVSTGGR VLCVTALGSD LSAAQKRAYE ALEYIKMDNA YYRKDIGFKG
     FK
//
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