ID A0A1B8BVR3_9PEZI Unreviewed; 1435 AA.
AC A0A1B8BVR3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=VE00_11041 {ECO:0000313|EMBL:OBT38696.1};
OS Pseudogymnoascus sp. WSF 3629.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT38696.1, ECO:0000313|Proteomes:UP000091997};
RN [1] {ECO:0000313|EMBL:OBT38696.1, ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT38696.1,
RC ECO:0000313|Proteomes:UP000091997};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
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DR EMBL; KV454807; OBT38696.1; -; Genomic_DNA.
DR STRING; 1622147.A0A1B8BVR3; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000091997; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000091997}.
FT DOMAIN 31..418
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 497..665
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 713..806
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 824..1114
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1125..1317
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 755..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1435 AA; 162837 MW; 6F93000F0C4C36D8 CRC64;
MAPRTRGPAE PRKEVDYGRP TVADLQGESP FAQLAKKHWL KPSKKAAKVK IKPQVLKKEI
WDVLEQEGFS YKTLLVLENL QILESYLWPG FSDDASNHHV LLIVLISNVR SREHLPVWSI
YSDNPADFSL LFRRILSMTL DNTLSPNIRT HLLSFIISAF QSLDSGIVRK ECAPLVSIAV
WHNLSSEKKR NNKLDESVQL RKVWRASGKR YEAADDTAKA RLRFERSWLY AMLLDFFSQL
HDTKNKSDNL LYCERFLELL SDFQSQLPTR RFVNTLLQDL NTLPLIRLSP LFNDEGSGLL
RDLYGLLKHY TYFSLDDHTG IQYTGEETYE RHCTQLGRLQ RTALKHYKDK LTILALSNYG
SIEKREDLEG HLETLSDDEL KAYCELLDLR VSYPDSANVA GGRPFLMEVL VSTFERRKTF
QDTARDLSIL PTEETLFEPT LLRNESYNGS QPLALPKLNL QYLTVGDFLW RSFILHRCES
FFEIRKDIED TLKRLRPQTS RTGETKFDGF SKMALPISKP AILEVVPPLV GETKPAAVKA
EIALDMSRLA ENIRREWESL RPDDVVFLLA ISLSDRSNMI SNGESKISDQ QKLGIRHIRA
AEVTQVLDDN GRPMRDFNGQ TNSRGQARLR RLHIKLDAAM YKQDLDSAAA GKPDVYESIN
VIVRRRGREN NFKSVLESIQ SLTLSDVPLA PWLHEVFLGY GDPAGASYPQ LANKIKKVDY
RDTFLNWHHL IESLPGKTVE PGEDASGSFG PPYVLKTTES VSAPTPTKPS KKRRRGQEDV
PANVAPPVVE VSTYKPPNTG PYPMDEVKLN HVRFTPAQVD AILSGTQPGL TVIIGPPGTG
KTDVATQIIN NIYHNFPKQR TLLIAHSNQA LNQLFQKIVA LDIDERHLLR LGHGEEELDT
ESNFSKHGRV ESFLENRDRY LLEVDRLAAN FGAPGAHGSS AETAGYFNSV YVEPAWARFQ
EALKDPEVTK EAVIELFPYH HYFSNAPQPL FPAEADKASV IEIASGCNYH VTKIFTELAD
VRPFEILRRD RDKANYLLTN EARIIAMTST HAAMRRREIA DLGFHYDNVI VEEAAQITEI
ENFIPLALQA PKNGMMPLQR VVLCGDHFQN SPIVQNLAFR QYANLEQSLF SRLVRLGVPT
VILDKQGRAR PSIAELYQWR YPHLGNLPLV ETGPEFQKSN AGFRYDYQFI NVPDYKGNGE
SEPTPHFIQN LGEAEYAVAI FQYMRLLGYP ASKISILTTY AGQRALIKDV LTHRCAKNPI
FGLPKIVTTV DKYQGEQNDH VILSLTRTSR VGYLRDVRRL TVALSRARLG LYILGRREVF
ESCFELQQAF EILFRRPDKL MLVTGELWPS QRTIADEADD VEVSGVTPME GVEHLGQYVF
EMTNAKVQQL RAERGLGEDV DVLAAVEEMD EEEVVVDGEV EEETPVDGFE AEEEE
//
