ID   A0A1B8C1S4_9PEZI        Unreviewed;       503 AA.
AC   A0A1B8C1S4;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=aspartyl aminopeptidase {ECO:0000256|ARBA:ARBA00011965};
DE            EC=3.4.11.21 {ECO:0000256|ARBA:ARBA00011965};
GN   ORFNames=VE00_09279 {ECO:0000313|EMBL:OBT40777.1};
OS   Pseudogymnoascus sp. WSF 3629.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT40777.1, ECO:0000313|Proteomes:UP000091997};
RN   [1] {ECO:0000313|EMBL:OBT40777.1, ECO:0000313|Proteomes:UP000091997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT40777.1,
RC   ECO:0000313|Proteomes:UP000091997};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT   white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000091997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT   white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal aspartate or glutamate from a
CC         peptide, with a preference for aspartate.; EC=3.4.11.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00001335};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|ARBA:ARBA00008290, ECO:0000256|RuleBase:RU004386}.
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DR   EMBL; KV454678; OBT40777.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B8C1S4; -.
DR   STRING; 1622147.A0A1B8C1S4; -.
DR   OrthoDB; 1156at2759; -.
DR   Proteomes; UP000091997; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05658; M18_DAP; 1.
DR   Gene3D; 2.30.250.10; Aminopeptidase i, Domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; ASPARTYL AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR28570:SF3; ASPARTYL AMINOPEPTIDASE; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000256|RuleBase:RU004386};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091997};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004386}.
FT   REGION          188..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  54844 MW;  C9267B5B94E4D631 CRC64;
     MATARVDDFL DFVGSSPTPF HAVQSAIKRL ESSGFKPILE RESWSTTLQP GGKYYLTRNG
     SSIVAFAIGT KWKSGNPIAM IGAHTDSPTL RLKPVSKKTN SGFLQIGVET YGGGIWHTWF
     DRDLSIAGRV MVRDKEGNFV QTLVKVDRPI VRIPTLAIHL DRSSEFNPNK ETELFPIAGL
     VAAELNRTGA KPDEKKSEDE AGEDSHASPL RAMTERHHPY IMEIIAEHAG VEVQDVIDFE
     LVLYDTQPPC RGGLNNELIY SARLDNLEMT YCAVLGLIES LSAPDALADE SSIRLIACFD
     HEEIGSTTAQ GAASNLLPAV LRRLSVLPAH ESGSEVSYEK VRRESDADIS TAYEQTLASS
     FLISADMAHS VNPNYAQKYE SDHRPEMNKG TVIKINANAR YATSSPGIVL LQEMARKAKS
     TTKGEGGVPL QLFVVRNDSS CGSTIGPMLS AALGTRTLDL GNAQLSMHSV RECGGAEDVE
     HAVRLFESFF ENFSALEGKI LVD
//