ID A0A1B8C301_9PEZI Unreviewed; 597 AA.
AC A0A1B8C301;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 08-NOV-2023, entry version 27.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN ORFNames=VE00_09072 {ECO:0000313|EMBL:OBT41160.1};
OS Pseudogymnoascus sp. WSF 3629.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT41160.1, ECO:0000313|Proteomes:UP000091997};
RN [1] {ECO:0000313|EMBL:OBT41160.1, ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT41160.1,
RC ECO:0000313|Proteomes:UP000091997};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
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DR EMBL; KV454666; OBT41160.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8C301; -.
DR STRING; 1622147.A0A1B8C301; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000091997; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000091997};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 170..245
FT /note="PX"
FT /evidence="ECO:0000259|Pfam:PF00787"
FT DOMAIN 301..487
FT /note="Sorting nexin/Vps5-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09325"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 65343 MW; 2FCD69BE7E2B8A65 CRC64;
MDYSSSLHDG DNPAEASPWG SSSAPSPQHN RTSFNPTPEA PGSPVYGQNR PHGDNYTSDS
GIAGGPGLSD EAENAHAYDQ RQDTTEPNVE HQGPQPVEQQ PADYSEQQRQ PHPGQDAQRQ
QRAPQPAARQ GPHYKLQAKI TGLERVGRKD PILRFDVHTN LPAFRTTQFR DVRRTHSEFI
KLADHLISSN PEAIVPAVPP ALTSAGAGTD EDEARVKASL QRWLNYVCGN DVLMRDDEMV
LFVESDYGYS PMVKRKQPAT GVRRKVIKQF APPPDDTPEL EDARPAIKQF YLGTMDAGHK
VDKLVKARKG LGLAESDFGV KLGTMSIQEL HGGLANAYRK LGKTIQTTGD FHAAQGTAEA
TTIGDPLAYH SEDAFIVKET LTNRHILMRE LLQAEILSKS KVDAADRLKV SSSVKREKVD
EAIAAMDKAR SNELHLRSKT QRVTGNLVQE TRRWFNRTTI DMRVSLREYV LREIEAERRT
LATLETIRPD IRAIDASGGL SRLGRESHPA ARRASLAASQ GPKGDAWSGV PRRPDASRNV
SSTIVPAVDE ETAEASAGRG RALSGDSSGG LAGVKEEEDD DRVDARNAAS RLATSTF
//
