ID A0A1B8C4T0_9PEZI Unreviewed; 994 AA.
AC A0A1B8C4T0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Poly A polymerase head domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE00_06690 {ECO:0000313|EMBL:OBT41847.1};
OS Pseudogymnoascus sp. WSF 3629.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT41847.1, ECO:0000313|Proteomes:UP000091997};
RN [1] {ECO:0000313|EMBL:OBT41847.1, ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT41847.1,
RC ECO:0000313|Proteomes:UP000091997};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the TTI2 family.
CC {ECO:0000256|ARBA:ARBA00034736}.
CC -!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
CC polymerase family. {ECO:0000256|ARBA:ARBA00007265,
CC ECO:0000256|RuleBase:RU003953}.
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DR EMBL; KV454649; OBT41847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8C4T0; -.
DR STRING; 1622147.A0A1B8C4T0; -.
DR OrthoDB; 5402987at2759; -.
DR Proteomes; UP000091997; Unassembled WGS sequence.
DR GO; GO:0110078; C:TTT Hsp90 cochaperone complex; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001680; P:tRNA 3'-terminal CCA addition; IEA:UniProt.
DR CDD; cd05398; NT_ClassII-CCAase; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3090.10; cca-adding enzyme, domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002646; PolA_pol_head_dom.
DR InterPro; IPR032828; PolyA_RNA-bd.
DR InterPro; IPR018870; Tti2.
DR PANTHER; PTHR13734:SF5; CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13734; TRNA-NUCLEOTIDYLTRANSFERASE; 1.
DR Pfam; PF01743; PolyA_pol; 1.
DR Pfam; PF12627; PolyA_pol_RNAbd; 1.
DR Pfam; PF10521; Tti2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81891; Poly A polymerase C-terminal region-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000091997};
KW RNA-binding {ECO:0000256|RuleBase:RU003953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003953}.
FT DOMAIN 54..198
FT /note="Poly A polymerase head"
FT /evidence="ECO:0000259|Pfam:PF01743"
FT DOMAIN 248..284
FT /note="tRNA nucleotidyltransferase/poly(A) polymerase RNA
FT and SrmB- binding"
FT /evidence="ECO:0000259|Pfam:PF12627"
FT REPEAT 732..770
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT COILED 935..962
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 994 AA; 111349 MW; AFB32FDD003BBA32 CRC64;
MASASMGQST LRPEDVVATA RITLTPQESK LRNLLLDVAR YIDESKEIKE RLELRFAGGW
VRDKLLAIPS NDIDTAINSM TGYAFSLKMK EYLDVPENRR KHGIENVSSL HKISANPEKS
KHLETVTTKL LGYDLDFVNL RKETYTVDSR NPQMEFGTAR EDALRRDATI NALFYNIHTD
EVEDFAGGLA DLDARLIRTP LEPHQTFVDD PLRVLRLIRF ASRLNFRIDT DSELSMGDPA
ILDALKLKIS RERVGVEIEK MMSDKNTRTA FDLIDRLGLY TTIFTNPTAE RFPQVDTSNW
KNAYNCLDLI KSNESPASIY KLLVRSDESE AVAWVLAALS PWASLGSPPR PPGGKLPLPY
ATFAAREGIK SNNKICDVVT GASRHFREII DLKAAVLAKE SHVYERDTLG MTIRRWDANG
GQWKLHVVLA ILVESMATDV TDGYDTFLQQ WQKFLDHIID MDLLEAATCK RIIDGKQLSK
ELKAKPGIWM AAALDLVMAW QFRNPTETDP RGAIEEKTAK AAILERCLQS REKLSLEDGD
SVAMQELIAW LIETIRPDGA CFLDASFDEA NSAEIEKSRE EWRFTSIFAL KSIKLLISYG
LISEASTMSE VLLGLLAFTQ LGDTWNSKPA YQISMDALDH QSQEVHAGAF IVGYVLKGFI
RPLFAKSTPQ TITSQGRKAP NENLGNRIAQ VASSPDAISK PWKCKDVHAV TVFKWVVTRA
DEGLISNNWH LFIPPLMTLL DDPTTSVRAS GLTILSEFLK RTSPRMLVQT GLSDLLEEAL
MPTLSFLPTL TPVAESQLLL QKAYAALLEL GDIRYSSEDD KLERNRFYDR LMREGIFYGI
HHCGDITIIM ELLLADMSEI INRLHIYSVK HAKDILPLLS AVLVDPFAPS NPALLLRGIK
TVQTTILNCW PILSEEHHRV QIVKALSICW INLTEEIMNS ASENVKNELV QLKQELQVSA
ALLCKSTGGT TGQGTALTDV VNVYPDLSNL FKLE
//
