ID A0A1B8C7I5_9PEZI Unreviewed; 1221 AA.
AC A0A1B8C7I5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE00_08154 {ECO:0000313|EMBL:OBT42807.1};
OS Pseudogymnoascus sp. WSF 3629.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT42807.1, ECO:0000313|Proteomes:UP000091997};
RN [1] {ECO:0000313|EMBL:OBT42807.1, ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT42807.1,
RC ECO:0000313|Proteomes:UP000091997};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV454631; OBT42807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8C7I5; -.
DR STRING; 1622147.A0A1B8C7I5; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000091997; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000091997};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 80..146
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 746..866
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 926..1173
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 134612 MW; DAC0038A0CB7BC57 CRC64;
MATMREHSER SAHVAPLHIH RGHYSESRSV DMTSNGSTVR QNSNASEYSA YSGTQITPPA
TPSAYGGDVT MTEMDYPRPV FHNYLRAVYP FNRAESPLEA AVTLHLDKGD VVLVYSIHTN
GWADGTLLLD GERGWVPTNF CENYEPEEMR SLLRALICFS DLLKSGITAE DEIFSNQEFI
KGIIAGVRLL LERLNCLTRD SPFVLSNEIV RRSRRSLLSD VSSLVKTSKH LQAYREHMFT
MTEPENISQG IIDEMLLKAF KIVTRGVRFH DACLADMESQ YTLNRITSLT LNPFDPSTPP
ADATTFQNAM SRASAGSRRE PLRISTGAAS REQPAEEETK RLSYKRTSSV FSPTAQNPRR
QSSMQLSRQS LSHRLSTAGQ HIEARRQNHV SGLLGSTHET FISCLGSLVG RLHLANGPSD
LLISIRQAIA AGKALGTIIE SLCARDVRGE AALQDVRDTM YQCINQLVIA ARECVRPSSS
DGEDNVLLQK DHDSIESAAT GCVVAVGECV DRAKSVIEMV GDYEPELSAL GIDVSAFAAD
VATDNNPRII EESTLEEPAS LPPPPPTGFD FETTLPPSVA DMEKHLPSFV IIDQEKPLPL
VPESEAETSD DAQMGLIGTA KTTLAPSPTF LPALKLGGPM GGLQLQTSLS SNDLLSSRSD
SVATCTGSPS TYMSSLRGSE ASLVSQTSTR ATTPELSTCR QSYQSHQVSK SVNSIPDSQA
TSADEREDDE SRVLEKTFAH ELIFNKERQV TGGSLPALVE RLTSHDSTPD ATFVSTFYLT
FRLFATPITF SEALIERFNY VNESLHIAAP VRLRVYNVFK GWLETHWQHT ADEVALPLIR
SFAETTLLSV LPQAGRRLSE LAEKVASIEG PITPRLISSI GKTSTSIAQY ISPDTPLPAP
ILSKSQINSL KTWKMGGSSP SILDFSPVEM ARQLTIKEMN VFCTIMPEEL LASEWMKKSG
SNAVNVKAMS TLSTDLSNLV ADTVLQSESD AKKRAVIIKH WIKIANECLI LNNYDSLMAI
ICSINSSMIT RLKKTWDMIS PKRKEMLKVL QDIVEPTKNH AVLRQRLQGH VPPCLPFVGT
YLTDLTFVDM GNPATKQLTG SAGEKGMAVI NFDKHTRTAK IIGDLQRFQI PYRLAEVPEL
QEWIQAQVIR VRASNDSNNV QQYYRKSLLL EPRMTQKTSP VDFQGAFSAH PTPILTKEKF
DLFSWAHTRD KLALTPTPTN S
//
