ID A0A1B8CBX6_9PEZI Unreviewed; 1280 AA.
AC A0A1B8CBX6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Antiviral helicase SKI2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE00_05858 {ECO:0000313|EMBL:OBT44315.1};
OS Pseudogymnoascus sp. WSF 3629.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT44315.1, ECO:0000313|Proteomes:UP000091997};
RN [1] {ECO:0000313|EMBL:OBT44315.1, ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT44315.1,
RC ECO:0000313|Proteomes:UP000091997};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; KV454608; OBT44315.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8CBX6; -.
DR STRING; 1622147.A0A1B8CBX6; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000091997; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 1.20.1500.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000091997};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 321..477
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 605..806
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 201..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1280 AA; 143348 MW; 73FD49681F0854A7 CRC64;
MAEALAESLQ KVHISSTADS RDDAWIDSIL DQQGPRKRVK QHPDDLKREL DRKFLTPSTS
FSTEWLNKLQ QRWDCPTDYT DLFKIAPTQT RTITRFTREG LEGRVTGYKE VTVPANSATA
KNSTSLLRKP GNRAEFVRGA AGFFPFAPGG LEGVEQAAAL EEQMMRVEGK GVAGAAKLER
VINFGAGDGL LEVAPGFKRG VSFKPKKGRG EEVEAEEVEK VLDQEPVEDE GLERGQEESP
GRGLEEEEED EEEEDIDSIL PVEFAAFEPR SALATSAAKR GAREWAHMVD IKRGITNFRE
LVPDMAREWP FELDTFQKEA VYHLENGDSV FVAAHTSAGK TVVAEYAIAL AAKHMTKAIY
TSPIKALSNQ KFRDFRQIFD EVGILTGDVQ IAPEASCLIM TTEILRSMLY RGADLIRDVE
FVIFDEVHYV NDLERGVVWE EVIIMLPEHV TLILLSATVP NTYEFASWVG RTKKKDIYVI
STAKRPIPLE HYLWANKEIH KIVDSDKKFI EKGWKAANDA MSGRDKIKAL PPAEASGRGR
GDSRGGRGDR GGRGGNQRGG AQRGGAQQRG RGGPPRASHN PGHMGRGGRP GGRTSAAQDK
TLWVHLVQFL KKESLLPACI FVFSKKRCEE NADALSNQDF CTAIEKSAIH MTIEKSIARL
KPEDRVLPQI VRLRDLLGRG IAVHHGGLLP IVKEVVEMLF AQTLVKVLFA TETFAMGLNL
PTRTVVFSGY RKHDGHSFRN LLPGEYTQMA GRAGRRGLDT IGTVIIVAPG GDEAPPVTEL
RQMILGEPSK LRSQFRLTYN MILNLLRVEA LKIEEMIKRS FSEHATQQLL PEHEKQVKIS
EADLAKIKRE PCDICDVDLE ACHQAGQEYM QLTLDLHLGV LGTPVGRRMF APRKLVVYMK
DGVRTPGILL REGATSGPNP TIHVLEIRTR RDVRDSTDLL PFLPQYREMM TKLPQAKKHI
STKTLWVPVT DLICVTKTTL KGIVPEIFQG GDGYLAAVAE LSRLCQSWTL PEWDELDWSK
IKDMTTRELL EKRRQVAEAA QQGACISCPE FLKHYAMRQD EWVIKENIHQ LRQLMSDQNL
QLLPDYEQRI QVLRDLSFID DTSRVELKGK VACEIHSADE LVLTELILDN VLAAYEPAEI
VALLSAFVFQ EKTDTVPTLT PNLKAGMATI IEISEKVNAV QTLHQVILST EDSNDFVSRP
RFGLVEVVYE WARGMSFRNI TDLTDVLEGT IVRVITRLDE TCREVKNAAR IVGDPELFLK
MQKCQEMIKR DITAVASLYM
//
